IDENTIFIKASI POLIMORFISME lle105Val GEN Glutathione S-Transferase Pi-1 (GSTP1) PADA EMPAT ETNIS MAYOR PENDUDUK KOTA PALEMBANG

AGUSDIANTO, AGUSDIANTO and Saleh, Mgs. Irsan and Yuwono, Yuwono (2013) IDENTIFIKASI POLIMORFISME lle105Val GEN Glutathione S-Transferase Pi-1 (GSTP1) PADA EMPAT ETNIS MAYOR PENDUDUK KOTA PALEMBANG. Undergraduate thesis, Sriwijaya University.

	Text RAMA_11201_04091001077.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (39MB) | Request a copy
Preview	Text RAMA_11201_04091001077_0029096608_0010107105_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (10MB) | Preview
	Text RAMA_11201_04091001077_0029096608_0010107105_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (7MB) | Request a copy
	Text RAMA_11201_04091001077_0029096608_0010107105_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_11201_04091001077_0029096608_0010107105_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (6MB) | Request a copy
	Text RAMA_11201_04091001077_0029096608_0010107105_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (884kB) | Request a copy
	Text RAMA_11201_04091001077_0029096608_0010107105_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11201_04091001077_0029096608_0010107105_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (10MB) | Request a copy

Abstract

Background: Patients demonstrated response variability on drug delivery is still a problem in pharmacotherapy. One important factor that led to the phenomenon of occurrence is the difference between the ability of individuals to metabolize the drug. The enzyme glutathione S-transferase (GST) is enzyme that play a role in the process of phase II metabolism with one of the main components is glutathione S-transferase Pi-1 (GSTPI). Polymorphism in the coding gene for the enzyme GSTPl may affect the ability of GST enzyme to detoxify xenobiotics that have potency as carcinogenic. The purpose of the study is to indcntify the lle/05Val polymorphism ofGSTPl gene. Methods: This slu<ly is a labornlory research, is also an observasional descriptive study of 69 subjects from four major ethnics of Palembang population, are Melayu, China, Arab, and India ethnics. Identification of lle/05Val polymorphism GSTPI gene was done by using PCR amplification and RFLP (restriction fragment length polymorphism) technique using enzyme BsmAJ. Results: The genotype AA was found as much as 68,1%, 31,9% genotype AG, and not met genotype GG. Genotype AA as many as 36.2% in men and 31.9% in women. While the genotype AG was found as much as 20,3% in men and 11,6% in women. Genotype AA was found as much as 14,5% in the ethnic of Melayu, 27,5% in the ethnic China, 14,5% in the ethnic Arah. and 11.6% in the ethnic India. While genotype AG was found as much as 1l ,6o/o in the·ethnic of Melayu, 5,8% in the ethnic China, 11,6% in the ethnic Arab, and 2,9% in the ethnic India. Conclusion: The overview of genotype AA (wild type) were more common in four of mayor ethnics of Palembang population (68,1%).

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	xenobiotic detocfication, polymorphism, GSTP1 gene
Subjects:	R Medicine > RJ Pediatrics > RJ47.3-47.4 Genetic aspects
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Mrs Furika Furika
Date Deposited:	09 Jan 2023 03:22
Last Modified:	09 Jan 2023 03:22
URI:	http://repository.unsri.ac.id/id/eprint/85543

Actions (login required)

View Item