EFEK PEMBERIAN SELF-NANO EMULSION EKSTRAK WHITE TEA TERHADAP PROFIL INSULIN, PARAMETER STRES OKSIDATIF DAN MIKROANATOMI TESTIS PADA MODEL TIKUS DIABETES TIPE-2

AISYAH, JASMINE RANI and Shiyan, Shaum (2023) EFEK PEMBERIAN SELF-NANO EMULSION EKSTRAK WHITE TEA TERHADAP PROFIL INSULIN, PARAMETER STRES OKSIDATIF DAN MIKROANATOMI TESTIS PADA MODEL TIKUS DIABETES TIPE-2. Undergraduate thesis, Sriwijaya University.

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Abstract

White tea contains catechins which have pharmacological effects as antioxidants. This study used test animals in the form of male Wistar rats which were divided into seven groups: normal group, negative control (STZ-NA induced), positive control (STZ-NA and Glibenclamide induced), group 1 (STZ-NA induced and SNE base). , Group 2 (induced STZ-NA and SNE-white tea extract), group 3 (induced STZ-NA and white tea extract), and group 4 (induced STZ-NA and catechins). The purpose of this study was to determine the effectiveness of SNE-Extra white tea in treating type-2 diabetes, repairing oxidative stress, and testicular microanatomy. The parameters observed in this study were the insulin profile which included insulin levels in the body, the level of insulin resistance in the form of a homeostatic model assessment of insulin resistance (HOMA-IR), the level of damage to pancreatic beta cells in the form of a Homeostatic Model Assessment of Beta Cell Function (HOMA-ß). , parameters of oxidative stress including GSH and GPx, as well as testicular microanatomy parameters using Johnson's assessment, degree of necrosis, and level of fatty degeneration. This study shows that SNE-white tea extract is effective in increasing insulin levels, reducing insulin resistance, repairing pancreatic beta cells, improving oxidative stress, and improving testicular microanatomy.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	SNE-White tea extract, diabetes, oxidative stress, testes
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM283-298 Endocrinotherapy. Organotherapy R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Jasmine Rani Aisyah
Date Deposited:	06 Feb 2023 01:53
Last Modified:	06 Feb 2023 01:53
URI:	http://repository.unsri.ac.id/id/eprint/88930

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