The efect of ketogenic diets on neurogenesis and apoptosis in the dentate gyrus of the male rat hippocampus

Murti, Krisna and Irfannuddin, Irfannuddin and Sarahdeaz, Siti Fazzaura Putri and Santoso, Budi and Koibuchi, Noriyuki (2021) The efect of ketogenic diets on neurogenesis and apoptosis in the dentate gyrus of the male rat hippocampus. The Journal of Physiological Sciences, 71 (3). pp. 1-7. ISSN 1880-6562

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Abstract

Ketogenic diets (KD) have become popular diet to lose weight. However, the efect of such diets on brain function has not yet been clarifed. Thus, we aimed to study the efects of KD on the neurogenesis and apoptosis in the dentate gyrus by assessing the expression of Ki-67 and Caspase-3. Rats (n=24) were divided into four groups: control (normal diet), ketogenic diet (KD), time-restricted diet (TRD), and the combination of high-fat and time-restricted diet (CD) groups. The expression of Ki-67 in the TRD and CD groups was higher compared to others (P< 0.05), whereas no such diference was observed in the KD group. The number of Capase-3-positive cells decreased signifcantly in the TRD group (P< 0.05), but such decrease was not observed in the CD group. These results indicate that, although KD could be efective in reducing the body weight, possible adverse efect in the brain cannot be ignored. Keywords: Ketogenic diet, Time-restricted diet, High-fat diet, Ki-67, Caspase-3, Immunohistochemistry

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	04-Faculty of Medicine > 11718-Pathology Anatomy (Sp
Depositing User:	dr., Ph.D. Krisna Murti
Date Deposited:	11 May 2023 15:23
Last Modified:	11 May 2023 15:23
URI:	http://repository.unsri.ac.id/id/eprint/101473

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