UJI TOKSISITAS AKUT FRAKSI ETANOL DAUN KERSEN (Mutingia calabura L.) TERHADAP TIKUS JANTAN GALUR WISTAR DENGAN METODE FIXED DOSE PROCEDURE

RABBANI, BALQIS and Herlina, Herlina and Agustiarini, Vitri (2023) UJI TOKSISITAS AKUT FRAKSI ETANOL DAUN KERSEN (Mutingia calabura L.) TERHADAP TIKUS JANTAN GALUR WISTAR DENGAN METODE FIXED DOSE PROCEDURE. Undergraduate thesis, Sriwijaya University.

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Abstract

Kersen (Mutingia calabura L.) leaves have pharmacological effect as antioxidant, antibacterial, anti-inflammatory, antihyperuricemia, antiobesity, antidiarhheal, antihyperlipidemic, analgesic, anthelmintic. Kersen leaves contain secondary metabolites, alkaloid, flavonoid, tannin, saponin, steroids. High flavonoid compounds require toxicity testing. This study aimed to determine the acute toxicity of ethanol fraction of Mutingia calabura L. leaves in vivo on Wistar strain male white rats by using fixed dose procedure method. In this study, 2 tests were carried out, the preliminary test and the main test (2 groups, normal & treatment at a dose of 2,000 mg/KgBW).The result of total flavonoid content in the ethanol fraction of kersen leaves is 139,50 mg QE/g or 13,95%. The result of observation in the main test showed that were no deaths or toxic symtomps in the test animal. Average level of biochemical parameters of normal group are SGOT 135,203  20,569 U/L, SGPT 86,372  12,604 U/L, creatinine 0,604  0,062 mg/dL, ureum 38,73  4,176 mg/dL whereas the dosage group of 2.000 mg/KgBB are SGOT 127,752  20,376 U/L, SGPT 75,576  8,406 U/L, creatinine 0,55  0,0616 mg/dL, ureum 36,916  2,257 mg/dL. A single dose of the ethanol fraction of cherry leaves at a dose of 2,000 mg/KgBW had no effect on the biochemical parameters of liver, heart, kidney and macroscopic functions of the liver, kidney and heart.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Daun Kersen, Mutingia calabura L., Toksisitas Akut, Fraksi Etanol, Fixed Dose Procedure.
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM146-146.7 Misuse of therapeutic drugs. Medication errors R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Balqis Rabbani
Date Deposited:	25 May 2023 04:56
Last Modified:	25 May 2023 04:56
URI:	http://repository.unsri.ac.id/id/eprint/105092

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