FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN OBAT KUMUR EKSTRAK ETANOL BUAH PINANG (ARECA CATECHU L.) TERHADAP BAKTERI STREPTOCOCCUS MUTANS SECARA IN VITRO

HANIYAH, ATIKAH and Untari, Budi and Wijaya, Dina Permata (2019) FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN OBAT KUMUR EKSTRAK ETANOL BUAH PINANG (ARECA CATECHU L.) TERHADAP BAKTERI STREPTOCOCCUS MUTANS SECARA IN VITRO. Undergraduate thesis, Sriwijaya University.

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Abstract

Areca extract (Areca catechu L.) was formulated into a mouthwash that aims to overcome caries. Areca nut (Areca catechu L.) contains tannin compounds that proanthocyanidin which can inhibit the enzymatic activity of glucosyltransferase from Streptoccus mutans. The ethanol extract of areca nut was formulated in three mouthwash formulas with variations in extract concentration of 1,25 %, 2,5 % and 5 %. Areca nut extracted by maceration using ethanol 96%. Mouthwashes was analyzed by using organoleptic, pH, specific gravity, stability and antibacterial activity. Antibacterial activity test employed agar diffusion method with paper disc divided into five groups, that was three mouthwash formulas with variations in extract concentration of 1,25 %, 2,5 % and 5 %, positive controls (minosep®) and negative control (formula without extract). The inhibition diameter zone measure was scaled by using ImageJ®. The higher concentration of extract with the increasing of antibacterial test against Streptoccus mutans. The results showed that the variations in the concentration of extracts affected organoleptic, pH, viscosity and specific gravity of the formulas. The inhibition zone was caused by the mouthwash with extract concentration of 1,25 % was 3,307 ± 0,887 mm, concentration of 2,5 % was 6,111 ± 0,290 mm and 5 % was 7,851 ± 1,272 mm.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	karies, buah pinang, obat kumur, Streptococcus mutans
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 2349 not found.
Date Deposited:	10 Oct 2019 02:26
Last Modified:	10 Oct 2019 02:26
URI:	http://repository.unsri.ac.id/id/eprint/11285

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