UJI EFEK ANTIDIABETES FRAKSI ETANOL BUNGA TELANG (Clitoria ternatea L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN

WULANDARI, AYUNI HARUM and Agustiarini, Vitri and Solihah, Indah (2023) UJI EFEK ANTIDIABETES FRAKSI ETANOL BUNGA TELANG (Clitoria ternatea L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN. Undergraduate thesis, Sriwijaya University.

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Abstract

Butterfly pea flowers (Clitoria ternatea L.) contains secondary metabolites of anthocyanins and flavonoids which have antidiabetic activity. The purpose of this study was to determine the effectiveness of lowering blood glucose levels of the ethanol fraction of butterfly pea flowers. The experimental divided into 6 groups namely normal and negative control groups with 0.5% NaCMC, positive control with insulin 1 IU/kgBW, and the ethanol fraction of butterfly pea flowers at doses of 100, 200 and 300 mg/kgBW. The rats were induced with alloxan 125 mg/kgBW until their blood glucose ≥126 mg/dL, then it was administered by the ethanol fraction of butterfly pea flowers for 14 days. Based on research results, the percentage reduction in blood glucose levels of rats given the butterfly pea flowers fraction were significantly different from the negative control (p <0.05), i.e dose of 100 mg/kgBW 45.30%; dose of 200 mg/kgBW 51.34%; and a dose of 300 mg/kgBW 54.57%. The dose of 300 mg/kg didn’t differs significantly from insulin (p>0.05). The ED50 value of the ethanol fraction of butterfly pea flowers as antidiabetic obtained was 191.01 mg/kgBW. Histopathological examination was performed using hematoxylin-eosin staining. Dose of 300 mg/kgBW had a better effect on repairing pancreatic beta cells than doses of 100 and 200 mg/kgBW.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Antidiabetes, Bunga Telang
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Ayuni Harum Wulandari
Date Deposited:	05 Jul 2023 02:06
Last Modified:	05 Jul 2023 02:06
URI:	http://repository.unsri.ac.id/id/eprint/114215

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