UJI AKTIVITAS SEDIAAN SPRAY GEL EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) TERHADAP LUKA BAKAR PADA KULIT TIKUS PUTIH JANTAN (Sprague dawley)

SIDIQ, MUHAMAD AAN and Herlina, Herlina and Wijaya, Dina Permata (2019) UJI AKTIVITAS SEDIAAN SPRAY GEL EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) TERHADAP LUKA BAKAR PADA KULIT TIKUS PUTIH JANTAN (Sprague dawley). Undergraduate thesis, Sriwijaya University.

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Abstract

Second degree burns include accidents that often occur in everyday life that can cause infection, dehydration etc. Ethanol extract of papaya leaves containing flavonoids and saponins has the potential to heal burns because they are anti-inflammatory, antioxidant, and antibacterial. This study aims to determine the variation of gel-forming agents that affect the healing process of burns. Ethanol extract of papaya leaves was formulated as a spray gel preparation to facilitate use and avoid additional contaminants when applied. Spray gel preparations were analyzed which included organoleptics, homogeneity, adhesion, pH, viscosity, pump delivery, spraying patterns, and washing ability. Variations in the combination of gelling agents in formula 1 gave adhesion 10,526 ± 0,435 seconds, pH 5,947 ± 0,015, viscosity 1740 ± 0 cPs, pump delivery 24,981 ± 0,012 g, spraying pattern 1,094 ± 0,009 cm, washed 3,267 ± 0,153 mL and% recovery burn wound healing by 82.92%. Spray gel preparations with a combination of gelling agents in formula 2 gave adhesion of 1.74 ± 0.036 seconds, pH 5.597 ± 0.015, viscosity of 880 ± 0 cPs, pump delivery 24,958 ± 0.015 g, spraying pattern 4,717 ± 0.071 cm, washed 2,300 ± 0.100 mL, and % burn recovery by 78.87%. Gelling agent spray in formula 3 gave adhesion 1.543 ± 0.050 seconds, pH 6.347 ± 0.015, viscosity 1440 ± 0 cPs, pump delivery 24.962 ± 0.021 g, spraying pattern 1,419 ± 0.021 cm, washed 3.867 ± 0.153 mL, and %recovery of burn wound healing by 83.43%. The test results for formula 1 and formula 3 for the preparation of gel spray of ethanol extract of papaya leaves can accelerate the healing of burn wounds.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	spray gel, gelling agent, daun pepaya, carbopol®940, gellan gum, hidroksietilselulosa, HPMC-60SH, luka bakar derajat II
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS400-431 Pharmaceutical chemistry
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 370 not found.
Date Deposited:	30 Jul 2019 04:08
Last Modified:	30 Jul 2019 04:08
URI:	http://repository.unsri.ac.id/id/eprint/1191

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