PENGARUH GEL EKSTRAK UBI JALAR UNGU TERHADAP JUMLAH FIBROBLAS SETELAH PENCABUTAN GIGI TIKUS WISTAR

SALSABILA, MEILYTA and Haksajiwo, Valentino (2023) PENGARUH GEL EKSTRAK UBI JALAR UNGU TERHADAP JUMLAH FIBROBLAS SETELAH PENCABUTAN GIGI TIKUS WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Tooth extraction is a minor surgical procedure with the aim of remove the tooth from the oral socket with use of specialized techniques and instruments. Tooth extraction will cause tissue injury. Purple sweet potato has potential as an alternative medicine for wound healing after tooth extraction that comes from natural materials. Purple sweet potato contains flavonoids, tannins, saponins, and anthocyanins that have contributed to the wound healing process, but there is no literature that explains the effect of purple sweet potato on the number of fibroblasts after tooth extraction. Objective: To determine the effect of 30% concentration of purple sweet potato extract on the number of fibroblasts after tooth extraction in Wistar rats. Methods: This type of research is true experimental with post test only control group design. The number of samples was 27 male Wistar rats with a division of 9 groups, which are 3 groups of purple sweet potato extract gel with a concentration of 30%, 3 positive control groups (Aloclair gel), and 3 negative control groups (Na-CMC base gel). The mandibular left incisor teeth were extracted, then the healing socket wounds in groups 1, 4, 7 were applied with 30% concentration purple sweet potato extract gel, groups 2, 5, 8 were applied with Aloclair gel, and groups 3, 6, 9 were applied with Na-CMC base gel with each group applied for 3 days, 5 days, and 7 days twice a day. Rats in groups 1, 2, 3 were euthanized on the 4th day, rats in groups 4, 5, 6 were euthanized on the 6th day, and rats in groups 7, 8, 9 were euthanized on the 8th day. The tissues were removed and histology preparations were made. The number of fibroblasts was counted using Olympus software and analyzed using One Way ANOVA test and post hoc follow-up test with LSD. Results: The average number of fibroblasts in the 30% concentration purple sweet potato extract gel group was lower than that in the Aloclair gel group, although the difference was not significant. Purple sweet potato extract gel with 30% concentration had a higher average number of fibroblasts than Na-CMC base gel with a significant difference. Conclusion: Purple sweet potato extract gel with 30% concentration has a significant effect in the increase in the number of fibroblasts in the wound healing process after tooth extraction of Wistar rats.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	ubi jalar ungu, fibroblas, pencabutan gigi, tikus Wistar
Subjects:	A General Works > AS Academies and learned societies (General) R Medicine > RB Pathology > RB24-33 Pathological anatomy and histology R Medicine > RK Dentistry > RK529-535 Oral surgery
Divisions:	04-Faculty of Medicine > 12201-Dentistry (S1)
Depositing User:	Meilyta Salsabila
Date Deposited:	17 Nov 2023 01:26
Last Modified:	17 Nov 2023 01:26
URI:	http://repository.unsri.ac.id/id/eprint/130541

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