UJI EFEK TERAPEUTIK EKSTRAK DAUN MORINGA OLEIFERA TERHADAP KADAR KOLESTEROL TOTAL DAN GAMBARAN HISTOLOGI HEPAR PADA MENCIT MODEL OBESITAS

SALSABILA, NUHA MARDHIYAH and Rasyid, Riana Sari Puspita and Larasati, Veny (2023) UJI EFEK TERAPEUTIK EKSTRAK DAUN MORINGA OLEIFERA TERHADAP KADAR KOLESTEROL TOTAL DAN GAMBARAN HISTOLOGI HEPAR PADA MENCIT MODEL OBESITAS. Undergraduate thesis, Sriwijaya University.

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Abstract

This research constitutes an experimental analytic study conducted in vivo, employing two parameters. The investigation of total cholesterol levels was conducted using a pre-test and post-test design with a control group. Conversely, the study of hepatic histology utilized a post-test with a control group design. Thirty male mice were allocated into five groups: a negative control, an obesity control with simvastatin, and obesity groups treated with varying doses of Moringa oleifera leaf extract (420, 630, and 840 mg/kg body weight). Prior to the treatment phase, each group was induced to develop obesity through a high-fat diet, marked by a Lee index>0.3, over a period of eight weeks. Subsequently, the animals were administered interventions daily according to their group allocations for a duration of 14 days. Total cholesterol levels were quantified pre- and post-treatment using Cholesterol (autocheck & GCU) and cholesterol strips, followed by the preparation of hepatic histological specimens for analysis of histological alterations.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Moringa oleifera, daun kelor, obesitas, kadar kolesterol total, non-alcoholic fatty live
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Nuha Mardhiyah
Date Deposited:	08 Jan 2024 02:58
Last Modified:	08 Jan 2024 03:11
URI:	http://repository.unsri.ac.id/id/eprint/137634

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