STUDI STABILITAS PROTRANSETOSOM KLINDAMISIN HCL DENGAN LIOPROTEKTAN SUKROSA MENGGUNAKAN METODE ICH Q1A (R2)

LESTARI, AYU DIAH and S, Annisa Amriani (2024) STUDI STABILITAS PROTRANSETOSOM KLINDAMISIN HCL DENGAN LIOPROTEKTAN SUKROSA MENGGUNAKAN METODE ICH Q1A (R2). Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061282025027.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_48201_08061282025027_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (4MB) | Request a copy
	Text RAMA_48201_08061282025027_0029128405_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (958kB)
	Text RAMA_48201_08061282025027_0029128405_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (621kB) | Request a copy
	Text RAMA_48201_08061282025027_0029128405_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (529kB) | Request a copy
	Text RAMA_48201_08061282025027_0029128405_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (789kB) | Request a copy
	Text RAMA_48201_08061282025027_0029128405_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (221kB) | Request a copy
	Text RAMA_48201_08061282025027_0029128405_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (469kB) | Request a copy
	Text RAMA_48201_08061282025027_0029128405_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

Clindamycin HCl has hydrophilic properties so if made in conventional topical formulations it has problems penetrating into the dermis layer. Transethosomes as a drug delivery system can be used in the transdermal route to increase the permeation of active substances. However, transethosomes in suspension form are still a challenge in terms of storage and stability. This study aims to overcome the stability problem of clindamycin HCl transethosomes through lyophilization with the addition of 2g/g sucrose lioprotectant to lipids so that clindamycin HCl protransethosomes are produced. The results showed that the lyophilized transethosome formula with the addition of sucrose could improve the characterization with % entrapment efficiency, particle size, PDI and zeta potential of 97.202 ± 0.140, 222.5 ± 14.58 nm, 0.353 ± 0.038, and -35.67 ± 1.332 mV, respectively. The stability results using the ICH Q1A(R2) standard showed that the release model of the lyophilized transethosomes with the addition of lioprotectant followed the first order with a better shelf life of about 227,963 days than the transethosome suspension with a shelf life of 32,566 at room temperature. The penetration test results showed that lyophilization with the addition of lioprotectant can increase the penetration rate and the zero-order release model showed sustained release. It can be concluded that the lyophilized transethosome formula with the addition of lioprotectant can improve the characterization results, shelf life of transethosomes and penetration rate.

Item Type:	Thesis (Undergraduate)
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Ayu Diah Lestari
Date Deposited:	19 Mar 2024 05:42
Last Modified:	19 Mar 2024 05:42
URI:	http://repository.unsri.ac.id/id/eprint/141751

Actions (login required)

View Item