UJI ANTINEFROLITHIASIS FRAKSI ETANOL DAUN MELINJO (Gnetum gnemon L.) TERHADAP TIKUS PUTIH JANTAN YANG DIINDUKSI ETILEN GLIKOL

JAHNA, MIFTAHUL and Eliza, Eliza and Herlina, Herlina (2024) UJI ANTINEFROLITHIASIS FRAKSI ETANOL DAUN MELINJO (Gnetum gnemon L.) TERHADAP TIKUS PUTIH JANTAN YANG DIINDUKSI ETILEN GLIKOL. Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061382025092.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (4MB) | Request a copy
	Text RAMA_48201_08061382025092_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (6MB) | Request a copy
	Text RAMA_48201_08061382025092_0029076403_0003077102_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (675kB)
	Text RAMA_48201_08061382025092_0029076403_0003077102_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (264kB) | Request a copy
	Text RAMA_48201_08061382025092_0029076403_0003077102_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (223kB) | Request a copy
	Text RAMA_48201_08061382025092_0029076403_0003077102_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061382025092_0029076403_0003077102_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (53kB) | Request a copy
	Text RAMA_48201_08061382025092_0029076403_0003077102_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (182kB) | Request a copy
	Text RAMA_48201_08061382025092_0029076403_0003077102_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy

Abstract

Melinjo leaves (Gnetum gnemon L) is one plant that has many properties, one of which is as a diuretic. Active compounds such as alkaloids, flavonoids, steroids, and tannins can be found in melinjo. Antinephrolithiasis testing of ethanol fraction of melinjo leaves was carried out in vivo with the aim of determining the effect on ureal levels, creatinine and calcium, crystalluria and urine pH, as well as macroscopic and histopathological images of rat kidneys induced ethylene glycol and ammonium chloride. In this study, there were seven test groups: normal group, negative group, positive group (Batugin), melinjo leaf ethanol fraction group dose 55, 110,165, and 220 mg/kg body weight. Ethylene glycol and ammonium chloride were given to the aal treatment group for 14 days except normal group and then followed by giving batugin and ethanol fraction of melinjo leaves in the positive group and dose treatment group for 14 days. The total flavonoid content of ethanol fraction of melinjo leaves is 4.866%. The results after induction were calcium oxalate monohydrate (COM) crystals and calcium oxalate dihydrate (COD) crystals in rat urine. The results showed that the average levels of creatinine, ureum, and calcium in the dose groups of 55, 110, 165, and 220 mg / kg body weight decreased compared to the negative control group. Post hoc statistical analysis of LSD creatinine, ureum, and calcium levels showed that the dose group of 220 mg/kgBB was not significantly different from the positive control group (p>0.05). The results of macroscopic and histopathological images of the kidneys showed kidney improvement after administration of ethanol fraction of melinjo leaves compared to the negative control group. The ethanol fraction of melinjo leaves dose 220mg/kg body weight is more effective in lowering creatinine, ureum, and calcium levels. The ethanol fraction of melinjo leaves dose 220 mg/kg body weight has antinephrolithiasis activity.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Gnetum gnemon, Antinefrolithiasis, Etilen Glikol, Amonium klorida, Kristaluria
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Miftahul Jahna
Date Deposited:	24 May 2024 01:25
Last Modified:	24 May 2024 01:25
URI:	http://repository.unsri.ac.id/id/eprint/145350

Actions (login required)

View Item