UJI HEPATOPROTEKTOR FRAKSI ETIL ASETAT DAUN MELINJO (Gnetum gnemon L.) DAN GAMBARAN HISTOPATOLOGI HEPAR TIKUS PUTIH JANTAN TERINDUKSI KARBON TETRAKLORIDA

PUTRI, AZZAHRA APRILIA and Herlina, Herlina and Ferlinahayati, Ferlinahayati (2024) UJI HEPATOPROTEKTOR FRAKSI ETIL ASETAT DAUN MELINJO (Gnetum gnemon L.) DAN GAMBARAN HISTOPATOLOGI HEPAR TIKUS PUTIH JANTAN TERINDUKSI KARBON TETRAKLORIDA. Undergraduate thesis, Sriwijaya University.

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Abstract

Melinjo leaves (Gnetum gnemon L.) have benefits in the field of traditional medicine. Melinjo leaves (Gnetum gnemon L.) contain secondary metabolite compounds such as flavonoids, saponins, tannins, phenolics, and saponins. This study aims to determine the hepatoprotector activity of ethyl acetate fraction of melinjo leaves (Gnetum gnemon L.) and hepatic histopathological picture of male white rats induced by carbon tetrachloride. The test was conducted for 14 days with a total of 35 rats divided into 7 groups, namely normal control (Na CMC 0.5% p.o), negative control (CCl4 mg/kgBB), positive control (Silimarin 100mg/kgBB), ethyl acetate fraction group of melinjo leaves (Gnetum gnemon L.) with doses of 10, 20, 40, and 80 mg/kgBB. The results of the study of the administration of ethyl acetate fraction of melinjo leaves (Gnetum gnemon L.) showed a significant difference (p<0.05) so that it can reduce SGPT and SGOT levels compared to the negative control. Based on the relationship of percent hepatoprotector to the dose of ethyl acetate fraction, the ED50 value of ethyl acetate fraction of melinjo leaves is 24.30 mg/kgBB. The ethyl acetate fraction of melinjo leaves can reduce SGPT and SGOT levels, but the 80 mg/kgBB dose gives the best results because the 80 mg/kgBB dose with the positive group gives an equivalent effect in reducing SGPT and SGOT levels (p>0.05) so that the 80 mg/kgBB dose gives the best macroscopic and histopathological picture of the liver compared to doses of 10, 20, 40 mg/kgBB, so it can be said that the 80 mg/kgBB dose is effective as a hepatoprotector induced by CCl4.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Daun melinjo (Gnetum gnemon L.), Hepatoprotektor, SGPT, SGOT, Hispatologi
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Azzahra Aprilia Putri
Date Deposited:	15 Jul 2024 06:23
Last Modified:	15 Jul 2024 06:23
URI:	http://repository.unsri.ac.id/id/eprint/150953

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