FORMULASI DAN UJI ANTIOKSIDAN ORALLY DISSOLVING FILM EKSTRAK ETANOL BUNGA KECOMBRANG (Etlingera elatior) BERBASIS PULLULAN DENGAN METODE DPPH

LESTARI, NABILA RIZKI and Miksusanti, Miksusanti and Wijaya, Dina Permata (2024) FORMULASI DAN UJI ANTIOKSIDAN ORALLY DISSOLVING FILM EKSTRAK ETANOL BUNGA KECOMBRANG (Etlingera elatior) BERBASIS PULLULAN DENGAN METODE DPPH. Undergraduate thesis, Sriwijaya University.

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Abstract

Kecombrang flower (Etlingera elatior) contains various secondary metabolite compounds, one of which is flavonoids that have antioxidant activity. Orally Dissolving Film (ODF) was formulated to cover the unpleasant taste of kecombrang flowers. Pullulan is used as a polymer due to its ease of solubility in water and has good film-forming properties. This study aims to determine the best formulation of pullulan-based ODF with variations concentration of ethanol extract of kecombrang flowers and to determine the antioxidant activity (IC50) using the DPPH method. The determination of the best formula is based on organoleptic evaluation, film weight, folding endurance, pH, disintegration time, percent elongation, film thickness, and percentage moisture loss. Uniformity of drug content was carried out on the best formulation. Based on the results, the total flavonoid content was 77.0072 mgRE/g. The increase in the concentration of ethanol extract of kecombrang flowers in the formulations had significant differences (p<0.05). The best formula obtained was formula 2. The best formula has a film weight of 36.6 mg, folding endurance of 488, pH 4.38, disintegration time of 14.48 seconds, percent elongation of 45.84%, film thickness of 0.063 mm, and percentage moisture loss of 5.63%. Antioxidant activity testing was carried out on vitamin C, ethanol extract of kecombrang flowers, and the best ODF formula of ethanol extract of kecombrang flowers. The test results showed that the IC50 value of vitamin C was 6.73 µg/mL, the IC50 value of ethanol extract of kecombrang flowers was 30.67 µg/mL, and the IC50 value of the best ODF formula of ethanol extract of kecombrang flowers extract was 1902.33 µg/mL. Keywords: Ethanol extract of kecombrang flowers (Etlingera elatior), orally dissolving film (ODF), pullulan, antioxidant, DPPH.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Ekstrak etanol bunga kecombrang (Etlingera elatior), orally dissolving film (ODF), pullulan, antioksidan, DPPH
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Nabila Rizki Lestari
Date Deposited:	29 Jul 2024 08:18
Last Modified:	29 Jul 2024 08:18
URI:	http://repository.unsri.ac.id/id/eprint/153382

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