PD-L1 EXPRESSION WITH ITS INFLUENCING PROGNOSTIC FACTORS IN EXTRANODAL NK/T CELL LYMPHOMA

Murti, Krisna and Fitria, Esti (2024) PD-L1 EXPRESSION WITH ITS INFLUENCING PROGNOSTIC FACTORS IN EXTRANODAL NK/T CELL LYMPHOMA. Majalah Kedokteran Sriwijaya, 56 (2). pp. 68-78. ISSN 2685-0486

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Abstract

Non Hodgkin Lymphoma (NHL), especially Extranodal NK/T cell Lymphoma (ENKTL) is a raremalignancy with an incidence rate of approximately 12% (168 out of 1,403 cases) of all NHL cases.Research by Aozasa et al., the frequency of ENKTL is estimated to be 10-fold higher in AsianpopulationswhencomparedtoEuropeans.AccordingtoWHO2022,extranodalNK/Tcelllymphoma, nasal type is often found in the respiratory tract, nasopharynx, paranasal sinuses, andpalate.ThistypeoflymphomaiscloselyassociatedwithEpstein-BarrVirus(EBV)infection.Overthe past decade, immunotherapy is, once again, a promising approach to cancer treatment, due to theremarkable salutary effectivenessofImmune-CheckpointInhibitors(ICIs) targeting ProgrammedCell Death-1 (PD-1) or Programmed Cell Death Ligand-1 (PD-L1). Programmed Death-Ligand 1(PD-L1) is an immune checkpoint protein that manipulates the host immune response by regulating Tcell function. ProgrammedDeath-Ligand 1 is overexpressed in EBV+ lymphoma cells especially inENKTL compared to EBV negative lymphomas and is associated with worse prognosis. In addition todetermining prognosis, PD-L1 inhibitors are used as cancer therapy. Programmed Death-Ligand 1expressedbyENKTLtumorcellsasatargetforPD-L1inhibitortherapy(pembrolizumab).Programmed cell death ligand 1 (PD-L1) overexpression was associated with the clinicopathologicalfactorsofBsymptoms,IPIscore, andAnnArborStage.SomestudiesexaminedtheexpressionofPD-1 and PDL1 in tumor cells and found PD-L1+ tumor cells was an independent poor prognostic factorforOS.Keywords:ExtranodalNK/Tcelllymphoma,Epstein-BarrVirus,ProgrammedDeathLigand1,StagingAnnArbor,Prognosis

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) #3 Repository of Lecturer Academic Credit Systems (TPAK) > Articles Access for TPAK (Not Open Sources)
Divisions:	04-Faculty of Medicine > 11718-Pathology Anatomy (Sp
Depositing User:	dr., Ph.D. Krisna Murti
Date Deposited:	19 Nov 2024 07:16
Last Modified:	19 Nov 2024 07:16
URI:	http://repository.unsri.ac.id/id/eprint/158271

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