KORELASI KADAR ANTIBODI ANTI-dsDNA DENGAN DERAJAT AKTIVITAS PENYAKIT PADA PASIEN LUPUS ERITEMATOSUS SISTEMIK DI RSUP DR. MOHAMMAD HOESIN

ADELIN, SALMANIYA ZAHRA and Yuniza, Yuniza and Rosdah, Ayeshah Augusta (2024) KORELASI KADAR ANTIBODI ANTI-dsDNA DENGAN DERAJAT AKTIVITAS PENYAKIT PADA PASIEN LUPUS ERITEMATOSUS SISTEMIK DI RSUP DR. MOHAMMAD HOESIN. Undergraduate thesis, Sriwijaya University.

	Text RAMA_11201_04011282126105.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_11201_04011282126105_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (4MB) | Request a copy
	Text RAMA_11201_04011282126105_8803600016_0030089002_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (2MB)
	Text RAMA_11201_04011282126105_8803600016_0030089002_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (933kB) | Request a copy
	Text RAMA_11201_04011282126105_8803600016_0030089002_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (374kB) | Request a copy
	Text RAMA_11201_04011282126105_8803600016_0030089002_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (329kB) | Request a copy
	Text RAMA_11201_04011282126105_8803600016_0030089002_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (177kB) | Request a copy
	Text RAMA_11201_04011282126105_8803600016_0030089002_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (190kB) | Request a copy
	Text RAMA_11201_04011282126105_8803600016_0030089002_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that involves various body systems and produces various autoantibodies. One of the autoantibodies in SLE is anti-double stranded deoxyribonucleic acid (anti-dsDNA) which is found in 70% of patients with SLE. Anti-dsDNA antibody has high specificity so it has been used as an indicator of disease activity. This study aims to determine the correlation of anti-dsDNA antibody levels with the degree of disease activity in SLE patients at RSUP Dr. Mohammad Hoesin. This study used an analytic observational study design with a cross sectional approach. Samples in this study were taken from medical records and laboratory examination results of SLE patients at RSUP Dr. Mohammad Hoesin. Samples that met the inclusion criteria were analyzed using the Spearman statistical test to identify the correlation between anti-dsDNA antibodies and the degree of disease activity using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). The total number of samples in this study was 33. Most patients were female (87.9%), most were in the age range of 18-44 years (87.9%), most had negative anti-dsDNA antibody levels (51.5%), and most had mild disease activity (54.5%). Bivariate analysis showed no significant correlation between anti-dsDNA antibody levels and MEX-SLEDAI score in this sample (p = 0.893). This study did not find a significant correlation between anti-dsDNA antibody levels and the degree of disease activity in SLE patients at RSUP Dr. Mohammad Hoesin. Keywords: SLE, Systemic Lupus Erythematosus, Anti-dsDNA, Disease Activity, MEX-SLEDAI

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	LES, Lupus Eritematosus Sistemik, Anti-dsDNA, Aktivitas Penyakit, MEX-SLEDAI
Subjects:	R Medicine > RB Pathology > RB37-56.5 Clinical pathology. Laboratory technique R Medicine > RC Internal medicine > RC581-607 Immunologic diseases. Allergy
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Salmaniya Zahra Adelin
Date Deposited:	16 Dec 2024 03:24
Last Modified:	16 Dec 2024 03:24
URI:	http://repository.unsri.ac.id/id/eprint/160361

Actions (login required)

View Item