UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL DAUN SUNGKAI (PERONEMA CANESCENS JACK) TERHADAP MENCIT (MUS MUSCULUS)

LIANI, CINDY DIVA and Agustiarini, Vitri and Fitrya, Fitrya (2025) UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL DAUN SUNGKAI (PERONEMA CANESCENS JACK) TERHADAP MENCIT (MUS MUSCULUS). Undergraduate thesis, Sriwijaya University.

Preview	Image RAMA_48201_08061282126069_Cover.jpg - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (333kB) | Preview
	Text RAMA_48021_08061282126069.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_48201_08061282126069_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_48201_08061282126069_0016089302_0010127203_01_front_ref.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_48201_08061282126069_0016089302_0010127203_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_48201_08061282126069_0016089302_0010127203_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_48201_08061282126069_0016089302_0010127203_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061282126069_0016089302_0010127203_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (392kB) | Request a copy
	Text RAMA_48201_08061282126069_0016089302_0010127203_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (397kB) | Request a copy
	Text RAMA_48201_08061282126069_0016089302_0010127203_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (222kB) | Request a copy

Abstract

The leaves of Sungkai (Peronema canescens Jack) contain secondary metabolites, flavonoids, which have the potential as antidepressant activity. This study aims to determine the effect of ethanol extract of Sungkai leaves on antidepressant activity and its optimal dose. In this study, six groups were divided: the normal group (NaCMC 0,5% without acute stress induction), the negative group (NaCMC 0,5% with acute stress induction), the positive group (fluoxetine 20 mg/kg body weight), and the treatment groups I, II, and III (ethanol extract of Sungkai leaves with doses of 100, 200, and 400 mg/kg body weight, respectively). Antidepressant testing for each group was conducted for 39 days. The parameters of traction test, tail suspension test, forced swimming test, and locomotor activity were measured on day 1, 7, and 14, while body weight was measured on days 0, 5, 10, 15, and 20, and sucrose consumption was measured. The results showed that the ethanol extract of Sungkai leaves had antidepressant activity in mice induced with acute stress, compared to the negative control (p<0.05). The study results indicate that the ethanol extract of Sungkai leaves has antidepressant activity, with a 400 mg/kg body weight dose showing antidepressant activity that was not significantly different from the positive control. Keywords: Antidepressant, Sungkai Leaves, Fluoxetine

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Antidepresan, Daun Sungkai, Fluoxetine
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Cindy Diva Liani
Date Deposited:	20 Mar 2025 02:15
Last Modified:	20 Mar 2025 02:15
URI:	http://repository.unsri.ac.id/id/eprint/169436

Actions (login required)

View Item