FORMULASI DAN KARAKTERISASI PATCH TRANSETOSOM EKSTRAK KULIT MANGGIS (Garcinia mangostana L.) TERPURIFIKASI 90% ALFA MANGOSTIN DENGAN VARIASI KONSENTRASI PROPILEN GLIKOL

AULIA, SARAH YASMIN and Wijaya, Dina Permata and Fithri, Najma Annuria (2025) FORMULASI DAN KARAKTERISASI PATCH TRANSETOSOM EKSTRAK KULIT MANGGIS (Garcinia mangostana L.) TERPURIFIKASI 90% ALFA MANGOSTIN DENGAN VARIASI KONSENTRASI PROPILEN GLIKOL. Undergraduate thesis, Sriwijaya University.

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Abstract

Alpha-mangostin as the main xanthone compound in mangosteen peel (Garcinia mangostana L.), exhibits pharmacological activities, including anti-inflammatory, making it a potential candidate for topical formulations. However, due to its limited penetration, a transethosome based patch is needed to optimize its effectiveness and usability. This study aims to develop a transethosomal patch preparation of alpha mangostin by evaluating the physicochemical characteristics to obtain the best formula. Transethosome patch were made by solvent casting method in 3 formulas that have different concentrations of propylene glycol. The best formula results were obtained in formula 3 with concentration of propylene glycol 20%, this can be seen from the characterization results including organoleptic, thickness, folding power, weight uniformity, % elongation, moisture, pH, and swelling index. The organoleptic results have an appearance, yellow in color, smooth surface, elastic, and have a distinctive odor of extract. The evaluation results of thickness, folding power, weight uniformity, elongation, pH, moisture, swelling index were respectively 0.300 ± 0.01 mm; >300 folds; 0.854 ± 0.027 mg; 104.875 ± 0.28%; 7.15 ± 0.03; 3.077 ± 0.01%; and 249.285 ± 2.899%. Compartmental analysis using WinSAAM® software showed that the patch followed the lag compartment model with 0th order release kinetics and the release mechanism followed Korsmeyer-Peppas. Stability test using the cycling test method on the best formula of transethosome patch showed no significant changes in organoleptic, content, moisture, and pH in the preparation with a value of p>0.05. Observation of content uniformity showed uniform results with % recovery 59.758% ± 1.266 and the morphology of the transethosome was still visible with a spherical vesicle shape in the patch preparation. The research results show that the transethosome patch of alpha-mangostin in formula III has good characteristics, stability, and penetration while maintaining the morphology of transethosomes, making it suitable for development as a transethosome patch. Keyword(s): alpha mangostin, patch, propylene glycol, solvent casting, transethosome

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	alfa mangostin, patch, transetosom, propilen glikol, solvent casting
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Sarah Yasmin Aulia
Date Deposited:	21 Mar 2025 01:45
Last Modified:	21 Mar 2025 01:45
URI:	http://repository.unsri.ac.id/id/eprint/169607

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