PERBANDINGAN EFEKTIVITAS ANTARA CARBOXYMETHYLCELLULOSE DENGAN SODIUM HYALURONATE PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN SINDROMA MATA KERING

OKTAVIYANI, FRESHCILIA and Tribowo, Anang and Kusnadi, Yulianto and Theodorus, Theodorus (2025) PERBANDINGAN EFEKTIVITAS ANTARA CARBOXYMETHYLCELLULOSE DENGAN SODIUM HYALURONATE PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN SINDROMA MATA KERING. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Dry eye syndrome is a common ocular complication in patients with type 2 diabetes mellitus, potentially impairing vision and quality of life. Sodium hyaluronate (SH) and carboxymethylcellulose (CMC) are commonly used topical treatments, but comparative data on their effectiveness and the influence of glycemic control are limited. This study objectives is to evaluate and compare the effectiveness of SH and CMC in improving clinical symptoms and signs of dry eye syndrome in type 2 diabetes patients, and to assess the correlation between HbA1c levels and therapeutic response. Methods: This randomized controlled trial (RCT) study involved patients type 2 diabetes with dry eye syndrome. Subjects were divided into two treatment groups: SH and CMC. Evaluations were performed at baseline, week 4, week 6 and week 8 using the Ocular Surface Disease Index (OSDI), Tear Film Break-Up Time (TBUT), and Schirmer’s test. Correlation analysis was conducted to examine the relationship between HbA1c and clinical improvement. Results: Both groups showed significant improvements in OSDI, TBUT, and Schirmer scores by week 4 (p<0.001 There was a correlation between HbA1c levels and the degree of improvement in OSDI scores (p<0.001), Schirmer test (p=0.001), and TBUT (p=0.001), indicating that better glycemic control enhances treatment efficacy. Conclusion: Sodium hyaluronate as effective as carboxymethylcellulose in improving subjective symptoms and tear film stability. Optimal HbA1c control is essential to maximize dry eye treatment outcomes in diabetic patients. Keywords: dry eye syndrome, sodium hyaluronate, carboxymethylcellulose, type 2 diabetes mellitus, HbA1c

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	sindroma mata kering, sodium hyaluronate, carboxymethylcellulose, diabetes melitus tipe 2, HbA1c
Subjects:	R Medicine > RE Ophthalmology > RE991-992 Ocular therapeutics
Divisions:	04-Faculty of Medicine > 11701-Eye Diceases (Sp-1)
Depositing User:	Freshcilia Oktaviyani
Date Deposited:	11 Jul 2025 02:29
Last Modified:	11 Jul 2025 02:29
URI:	http://repository.unsri.ac.id/id/eprint/177724

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