POLA SUSEPTIBILITAS STAPHYLOCOCCUS AUREUS DAN STREPTOCOCCUS PYOGENES TERHADAP EKSTRAK BONGGOL NANAS DAN ASAM FUSIDAT PADA PASIEN IMPETIGO

SUHERMAN, AHMAD LIGAR and Argentina, Fifa and Purwoko, Muhammad Izazi Hari and Harahap, Debby Handayati and Shiyan, Shaum (2025) POLA SUSEPTIBILITAS STAPHYLOCOCCUS AUREUS DAN STREPTOCOCCUS PYOGENES TERHADAP EKSTRAK BONGGOL NANAS DAN ASAM FUSIDAT PADA PASIEN IMPETIGO. Masters thesis, Sriwijaya University.

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Abstract

Background: Impetigo is a superficial epidermal infection most often caused by Staphylococcus aureus and/or Streptococcus pyogenes. Fusidic acid is one of the first-line topical therapies for impetigo in Indonesia. Antibiotic resistance is a challenge in treatment. Pineapple core extract (Ananas comosus (L.) Merr.) has major bioactive content such as bromelain which is antibacterial. Objective: Comparing the susceptibility of Staphylococcus aureus and Streptococcus pyogenes to pineapple core extract and fusidic acid in impetigo patients. . Method: Experimental in vitro research with post-test only control group design. The research samples were all Staphylococcus aureus and Streptococcus pyogenes bacteria from impetigo patients at the DVE Polyclinic, RSMH Palembang for the period January-March 2025. Resistance testing was performed with the disc diffusion method utilizing pineapple core extract (50%, 70%, and 100%) alongside fusidic acid. Results: The Mean diameter of the inhibition zone against the growth of Staphylococcus aureus by pineapple core extract at concentrations of 50%, 70%, and 100% were 6.74 ± 0.462 mm, 7.48 ± 0.522 mm, and 8.51 ± 0.578 mm, respectively. The mean diameter of the inhibition zone against Streptococcus pyogenes by pineapple core extract at concentrations of 50%, 70%, and 100% were 8.58 ± 0.349 mm, 9.59 ± 0.532 mm, and 10.69 ± 0.540 mm, respectively. Bivariate analysis showed a significant difference in the diameter of the inhibition zone of Staphylococcus aureus between the 10 µg fusidic acid group and 3 groups of pineapple core extract (p < 0.05), while in Streptococcus pyogenes there was no significant difference in the diameter of the inhibition zone of Streptococcus pyogenes between the 10 µg fusidic acid group and 100% pineapple core extract (p> 0.05). Multivariate analysis showed that there were significant differences between five groups (p = 0.000; p < 0.050). The susceptibility test of Staphylococcus aureus to fusidic acid was found to be 63.3% sensitive. The susceptibility of Streptococcus pyogenes to fusidic acid showed 100% sensitive. Conclusion: Pineapple core extract 100% has inhibition zone comparable to fusidic acid against Streptococcus pyogenes in impetigo, but the inhibition zone of pineapple core extract against Staphylococcus aureus is still lower than fusidic acid. Keywords: impetigo, Staphylococcus aureus, Streptococcus pyogenes, fusidic acid, pineapple core

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	ekstrak bonggol nanas, suseptibilitas
Subjects:	R Medicine > RL Dermatology > RL1-803 Dermatology
Divisions:	04-Faculty of Medicine > 11704-Dermatology and Venereology (Sp
Depositing User:	dr.,Sp.DVE Ahmad Ligar Suherman
Date Deposited:	15 Jul 2025 02:01
Last Modified:	15 Jul 2025 02:01
URI:	http://repository.unsri.ac.id/id/eprint/178478

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