OPTIMASI FORMULA DAN KARAKTERISASI TABLET SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM ASAM MEFENAMAT MENGGUNAKAN VARIASI PENGIKAT DAN PENGHANCUR DENGAN FACTORIAL DESIGN

AULIA, BETA and Untari, Budi and Wijaya, Dina Permata (2019) OPTIMASI FORMULA DAN KARAKTERISASI TABLET SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM ASAM MEFENAMAT MENGGUNAKAN VARIASI PENGIKAT DAN PENGHANCUR DENGAN FACTORIAL DESIGN. Undergraduate thesis, Sriwijaya University.

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Abstract

S-SNEDDS dosage form is a SNEDDS solidification developed to overcome the problems that still exist in SNEDDS such as in terms of stability, but has disadvantages in its use. The preparation into SNEDDS tablet dosage form aims to ease of use, ease of dosage management, and improve the stability. The characterizations of S-SNEDDS which have been done are water content, flow time, angle of repose, Hausner ratio, compressibility, granules size distribution, and granules size uniformity. The characterizations of SNEDDS tablet which have been done are weight uniformity, size uniformity, hardness, friability, disintegration time, and drug content. Formulation and optimization of SNEDDS tablet is using 22 factorial design method with Design Expert®10. The optimum formula for SNEDDS tablet is obtained by the type of binder in the form of 4% HPMC K4M and the type of disintegrant in the form of 10% starch which is chosen because it has the best desirability value equal to 0.779. Mefenamic acid SNEDDS tablet was able to increase the dissolution of mefenamic acid compared to mefenamic acid generic tablet and pure mefenamic acid with DE value (disolution efficiency) respectively 21.940 ± 0.027%; 17.864 ± 0.058%; 9.395 ± 0.009%. These results show that the SNEDDS tablet dosage form is capable of improving the dissolution of the mefenamic acid generic tablet, however, the results of characterization mefenamic acid SNEDDS tablet indicate that the tablet does not meet the requirements of the friability test therefore it does not meet the requirements to be made into tablet dosage form.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Mefenamic acid SNEDDS tablet, HPMC K4M, carbopol 934, starch, guar gum
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 624 not found.
Date Deposited:	02 Aug 2019 10:36
Last Modified:	02 Aug 2019 10:36
URI:	http://repository.unsri.ac.id/id/eprint/1957

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