STANDARDISASI DAN UJI ANTIINFLAMASI EKSTRAK ETANOL DAUN TAHONGAI (Kleinhovia hospita L.) TERHADAP TIKUS (Rattus norvegicus) JANTAN GALUR WISTAR

CHARMILA, OKTIA and Herlina, Herlina and Solihah, Indah (2017) STANDARDISASI DAN UJI ANTIINFLAMASI EKSTRAK ETANOL DAUN TAHONGAI (Kleinhovia hospita L.) TERHADAP TIKUS (Rattus norvegicus) JANTAN GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

The leaves of tahongai (Kleinhovia hospita L.) has been traditionally used in Komering tribes as phytotherapy to cure the inflammation related diseases including cancer, furuncles, polyps and tonsilitis. The aim of this study was to standardize the quality of tahongai leaves ethanolic extract by determining the specific and non specific parameters of extract and also evaluate the anti-inflammatory effect of extract against carragenan-induced paw edema volume in rats. The result of specific parameters extract showed that the organoleptic properties of tahongai leaves ethanolic extract were thick, brownish black in color, has characteristic odor, astringent with slightly bitter taste, the water and ethanol soluble extractive content were 19.263% ± 0.95 and 18.30% ± 0.51 respectively. The non specific parameters of tahongai leaves ethanolic extract showed the density of extract was 1.413 g/ml ± 0.04, the water content value of 21.16% ± 0.55, total ash content 15.64% ± 0.75, acid insoluble ash content 8.282% ± 0.28, total bacteria contamination 90.5 x 101 colony/g, and the total mold and yeast contamination of 1 x 101 colony/g. The result exhibited that the extract fulfill the general requirement as a qualified phytotherapy material. The anti-inflammatory study was carried out in 25 male Wistar rats which divided into 5 groups of treatment. Group I and II as negative and positive control given Na CMC 1% and diclofenac sodium respectively, group III, IV and V was given the extract by dosage of 250, 500, dan 750 mg/kgBW respectively. The oral administration of tahongai leaves ethanolic extract in 500 dan 750 mg/kgBW exhibited no significant difference (p >0.05) compared with the positive control which indicated the anti inflammatory activity of extract equals to diclofenac of dose 4.1 mg/kgBW. The effective dose (ED50) was calculated based on the mean of edema inhibition percentage, with a result of 605.04 mg/kgBW.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Kleinhovia hospita L., standardization, anti inflammatory, carrageenan, rat paw edema
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	03 Dec 2019 08:36
Last Modified:	03 Dec 2019 08:36
URI:	http://repository.unsri.ac.id/id/eprint/19825

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