Amin, Ramzi (2015) Peer Review_Ramzi_Amin_Relationship between Retinal Nerve Fiber Layer with Visual Field Defect in Non Proliferative Diabetic Retinopathy. Ophthalmologica Indonesiana, Persatuan Dokter spesialis Mata Indonesia (Perdami)).
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Abstract
Background: In the early stages of diabetic retinopathy, neuronal abnormalities include changes in ganglion cell death. Neuronal apoptosis is suspected as one of the causes responsible for the occurrence of lesions at an early stage of diabetic retinopathy, which results in a decrease in number of ganglion cells and thinning of the layer of ganglion cells, which can be caused by several mechanisms including glutamat excitoxicitate, oxidatice stress, hyperglichemia, and neuroinlamation. Retinal ganglion cell death and axonal degeneration, will cause thinning of the retinal nerve iber layer (RNFL) which may result in a decrease in neural function, which in turn have an impact on the occurrence of visual ield defects. This study is to determine the relationship between the thickness of RNFL with visual ield defects in patients with non-proliferative diabetic retinopathy (NPDR). Methods: This study is a comparative analytic cross-sectional design with sample of 66 eyes of 34 people in clinic of retina subdivision of Moh. Hoesin Hospital Palembang from July to November 2013. Patients of NPDR examined fundus photo, Oculo Coherence Tomograph and Humphrey Field analyzer. Results: RNFL thickness average in this study is 104.4±10.9 µm. Visual ield defect occur ini moderate and severe NPDR. Conclusion: There is a strong relationship between RNFL thickness with visual ield defects in patients NPDR (r =-0.693).
| Item Type: | Other |
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| Depositing User: | dr ramzi amin |
| Date Deposited: | 22 Jun 2020 14:11 |
| Last Modified: | 22 Jun 2020 14:11 |
| URI: | http://repository.unsri.ac.id/id/eprint/20089 |
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