Prawirohardjono, Widharto and Hidayat, Rachmat (2015) Telmisartan Prevents Myocardial Fibrosis : Telmisartan Decreases TGF-\ensuremathβ1 and Collagen Fraction Volume Myocardial Tissue in Wistar Rats Induced High Salt Intake. International Journal of Biological & Medical Research, 6 (3). pp. 5050-5054. ISSN 0976 - 6685
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Abstract
The beneficial effects from variation doses of telmisartan prevents myocardial fibrosis in wistar rats induced high salt intake.Ten-week-old male Wistar Rat (n = 30) were used. Wistar Rats were randomized into five groups. Group 1 : 6 rats as negatif control. Group 2 : 6 rats were induced for heart fibrosis by intake Nacl 8% doses 2% body weight for eight weeks. Group 3 : 6 rats were induced for heart fibrosis by intake Nacl 8% doses 2% body weight and telmisartan 3 mg/kgBB for eight weeks. Group 4 : 6 rats were induced for heart fibrosis by intake Nacl 8% doses 2% body weight and telmisartan 6 mg/kgBB for eight weeks. Group 5 : 6 rats were induced for heart fibrosis by intake Nacl 8% doses 2% body weight and telmisartan 12 mg/kgBB for eight weeks. Fraction volume collagen and concentration of TGF-\ensuremathβ1 in myocardial tissue were assessed. Fraction volume collagen and TGF- \ensuremathβ1 significantly decreased in group 4 (high salt intake and telmisartan 6 mg/kgBB) and 5 (high salt intake and telmisartan 12 mg/kgBB) compared in group 2 (only high salt intake).Telmisartan prevents myocardial fibrosis. Telmisartan decreases TGF-\ensuremathβ1 and fraction volume collagen in myocardial tissue wistar rats induced high salt intake.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology |
| Divisions: | 04-Faculty of Medicine > 11201-Medicine (S1) |
| Depositing User: | MD, M.Sc Rachmat Hidayat |
| Date Deposited: | 26 Dec 2019 04:07 |
| Last Modified: | 26 Dec 2019 04:07 |
| URI: | http://repository.unsri.ac.id/id/eprint/22232 |
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