AKTIVITAS ANTIDIABETES EKSTRAK DAN FRAKSI BUAH KARAMUNTING (Rhodomyrtus tomentosa (Aiton) Hassk) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI STREPTOZOTOSIN

MONISIA, FIRDA TRI and Herlina, Herlina and Ferlinahayati, Ferlinahayati (2020) AKTIVITAS ANTIDIABETES EKSTRAK DAN FRAKSI BUAH KARAMUNTING (Rhodomyrtus tomentosa (Aiton) Hassk) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI STREPTOZOTOSIN. Undergraduate thesis, Sriwijaya University.

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Abstract

Penelitian aktivitas antidiabetes ekstrak dan fraksi buah karamunting (Rhodomyrtus tomentosa (Aiton) Hassk) terhadap tikus putih jantan galur wistar terinduksi streptozotosin bertujuan mengetahuipengaruhpemberianekstraketanoldan fraksi etil asetat buah karamuntingterhadappenurunankadarglukosadarahtikusdiabetes mellitus tipe-2 dan mengetahuidosisefektifdarivariasiekstraketanol dan fraksi etil asetat buah karamunting. Delapan kelompok tikus dikondisikan diabetes mellitus tipe-2 dengan cara diinduksi streptozotosin dosis 60 mg/kgBB secara intraperitoneal. Kelompok kontrol negatif diberi NaCMC 0,5%, kelompok kontrol positif diberi metformin 173 mg/kgBB, kelompok I, II dan III diberi ekstrak etanol buah karamunting dosis 100 - 400 mg/kgBB, kelompok IV, V dan VI diberi fraksi etil asetat buah karamunting dosis 10 - 40 mg/kgBB. Perlakuan terhadap tikus diabetes mellitus dilakukan selama 15 hari dengan 4 kali pengukuran kadar glukosa darah, yaitu pada hari ke-0, 5, 10, dan 15. Kadar glukosa darah diukur menggunakan metode enzimatik (GOD-PAP) dengan alat fotometer. Penurunan kadar glukosa darah yang dihasilkan oleh metformin sebesar 30,91%, ekstrak etanol buah karamunting sebesar 32,02% - 39,70% dan fraksi etil asetat buah karamunting sebesar 43,74% - 45,79%. Penurunan kadar glukosa ekstrak etanol dosis 400 mg/kgBB dan fraksi etil asetat dosis 10 - 40 mg/kgBB berbeda signifikan dengan metformin (p<0,05). Berdasarkan hubungan persentase penurunan kadar glukosa darah terhadap dosis, maka dosis efektif (ED50) ekstrak etanol buah karamunting 2 kali dosis tertinggi yang digunakan dan fraksi etil asetat buah karamunting 2,5 kali dosis tertinggi. Kata kunci: Buah karamunting,Rhodomyrtus tomentosa, streptozotosin, GOD-PAP, kadar glukosa darah

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Buah karamunting,Rhodomyrtus tomentosa, streptozotosin, GOD-PAP, kadar glukosa darah
Subjects: R Medicine > RC Internal medicine > RC627.5-632 Metabolic diseases
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Users 4420 not found.
Date Deposited: 31 Jan 2020 03:48
Last Modified: 31 Jan 2020 03:48
URI: http://repository.unsri.ac.id/id/eprint/26700

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