UJI TERATOGENIK EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) PADA FETUS MENCIT (Mus musculus) GALUR SUB SWISS WEBSTER

HERNY, HENRY and Herlina, Herlina and Amriani, Annisa (2018) UJI TERATOGENIK EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) PADA FETUS MENCIT (Mus musculus) GALUR SUB SWISS WEBSTER. Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061281419046_0003077102_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB)
	Text RAMA_48201_08061281419046_0003077102_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (632kB) | Request a copy
	Text RAMA_48201_08061281419046_0003077102_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (453kB) | Request a copy
	Text RAMA_48201_08061281419046_0003077102_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061281419046_0003077102_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (8kB) | Request a copy
	Text RAMA_48201_08061281419046_0003077102_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (295kB) | Request a copy
	Text RAMA_48201_08061281419046_0003077102_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy

Abstract

Ethanolic 96% extract of red betel (Piper crocatum Ruiz & Pav.) is classified as non toxic based on the previous general toxicity test researches including acute and subchronic toxicity test with LD50 18 g/kgBW. The purpose of doing teratogenicity test is to know the effect of a sample towards the fetuses if being consumed by a pregnant woman. The ethanolic 96% extract of red betel’s dosages that were given are 50, 100, dan 200 mg/kgBW. The extract was given to the pregnant mice during the organogenesis period by the 9th until 17th day of pregnancy. On the 18th day, the pregnant mice was dissected to observe the fetuses’ weight, the amount of living fetuses, dead fetuses, implantation, resorption, the external abnormality of the fetuses, and the fetuses’ skeletal disorder. The data that has been statistically analyzed by ANOVA showed that the adduction of extract has a significant effect of the ossification delayed of interparietal bones and sacrocaudal vertebra curved bones (F counted > F table 0.05) and a very significant effect of the ossification delayed of sternum bones (asymetrically shaped) (F counted > F table 0.01). The DMRT (Duncan Multiple Range Test) showed that P2 dosage (100 mg/kgBW) was the minimum dosage that could result in the teratogenic effect on mice’s fetuses, so it can be concluded that ethanolic 96% extract of red betel has a teratogenic effect on mice’s (Mus musculus) fetuses.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Piper crocatum Ruiz & Pav., teratogenic, Mus musculus, ossification, pregnancy
Subjects:	Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Mrs Dies Meirita Sari
Date Deposited:	15 Jul 2019 08:21
Last Modified:	26 Jul 2019 16:18
URI:	http://repository.unsri.ac.id/id/eprint/273

Actions (login required)

View Item