HUBUNGAN KEPADATAN SEL PLASMA DENGAN KARAKTERISTIK KLINIKOHISTOPATOLOGI PADA DIFFUSE LARGE B CELL LYMPHOMA

CHODIJAH, NYIMAS and Murti, Krisna and Rasyid, Riana Sari Puspita (2021) HUBUNGAN KEPADATAN SEL PLASMA DENGAN KARAKTERISTIK KLINIKOHISTOPATOLOGI PADA DIFFUSE LARGE B CELL LYMPHOMA. Undergraduate thesis, Sriwijaya University.

	Text RAMA_11201_04011281722142.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (6MB) | Request a copy
	Text RAMA_11201_04011281722142_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (9MB) | Request a copy
Preview	Text RAMA_11201_04011281722142_0010126311_0017098502_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB) | Preview
	Text RAMA_11201_04011281722142_0010126311_0017098502_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11201_04011281722142_0010126311_0017098502_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (461kB) | Request a copy
	Text RAMA_11201_04011281722142_0010126311_0017098502_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (654kB) | Request a copy
	Text RAMA_11201_04011281722142_0010126311_0017098502_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (187kB) | Request a copy
	Text RAMA_11201_04011281722142_0010126311_0017098502_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_11201_04011281722142_0010126311_0017098502_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (441kB) | Request a copy

Abstract

Background: Diffuse Large B Cell Lymphoma (DLBCL) is a malignancy derived from malignant transformation of B cells from the germinal center. This type of non-Hodgkin's lymphoma is the most common and represents about 30-40% of all cases. The tumor microenvironment of B-cell lymphoma plays an important role in the regulation of tumor cell survival and proliferation. Plasma cells in the tumor microenvironment have an important role in formation the anti-tumor immune response, even in low numbers, these cells can produce large amounts of cytokines and antibodies. The purpose of this study was to determine the relationship between plasma cell density and clinicalohistopathological characteristics of DLBCL patients. Method: A cross-sectional study was conducted. The samples of this study were paraffin blocks of DLBCL patients referred to Anatomic Pathology Departement Faculty of Medicine Universitas Sriwijaya/RSUP Dr. Mohammad Hoesin Palembang. From 50 cases during the 2018-2020 period, 32 samples were selected. Plasma cells were morphologically identified on HE slides. Statistikal analysis was performed using the chi-square test with significant consideration if p <0,05. Result: The distribution of DLBCL cases found more in the age group <60 years (56,3%), male gender (68,8%), extranodal tumor location (56,3%). Centroblastic variants were higher (78,1%) than others, and the non-GCB subtype (78,1%) was higher than the GCB. There was no significant relationship between plasma cell density and age, sex, tumor location, variant and subtype. Conclusion: There is no significant relationship between plasma cell density and the clinicalohistopathological characteristics of DLBCL. Keywords: DLBCL, Plasma Cells, Clinicalohistopathology, Tumor Microenvironment.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Kata Kunci: DLBCL, Sel Plasma, Klinikohistopatologi, Lingkungan Mikro Tumor.
Subjects:	R Medicine > RB Pathology > RB24-33 Pathological anatomy and histology
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Users 10087 not found.
Date Deposited:	20 Jan 2021 04:52
Last Modified:	20 Jan 2021 04:52
URI:	http://repository.unsri.ac.id/id/eprint/40613

Actions (login required)

View Item