AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI ETIL ASETAT DAUN MELINJO (Gnetum gnemon L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI PROPILTIOURASIL

BELINDA, RAHMA and Herlina, Herlina (2021) AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI ETIL ASETAT DAUN MELINJO (Gnetum gnemon L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI PROPILTIOURASIL. Undergraduate thesis, Sriwijaya University.

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Abstract

A research about antihyperlipidemia activity of ethyl acetate fraction from Melinjo leaf (Gnetum gnemon L.) against white male wistar rats Induced by propylthiouracil has been done. Wistar male rats were divided into six groups, which are a normal group, a positive control group (simvastatin 0,987 mg/kgBW), a negative control group (NaCMC 0,5%), and the other three groups with a dose treatment of 10 mg/kgBW, 30 mg/kgBW, and 50 mg/kgBW. The cholesterol and triglycerides levels were measured by using enzymatic method of (CHOD-PAP) and (GPO-PAP). HDL levels were measured by using Cholesterol HDL Analysis Kit with a photometer instrument, and LDL levels were calculated by using indirect calculation. Decreased triglycerides levels at dose of 10 mg/kgBw and increased HDL levels at dose 30, 50 mg/kgBW were not significantly different with simvastatin (p>0.05), while decreased cholesterol and LDL levels at dose 10, 30, 50 mg/kgBW were significantly different with simvastatin (p <0,05). Based on the relationship between the percentage reduction in cholesterol, triglycerides, LDL and increased of HDL level, the effective ED50 of ethyl acetate fraction of Melinjo leaf is 34,74 mg/kgBW. Histopatological analyses of liver’s rat showed that dose of 50 mg/kgBW was the same as simvastatin in its %necrosis and %fat degeneration of 20%. These results indicate that the ethyl acetate fraction of Melinjo leaf acts as an antihyperlipidemia, and there is a significant difference compared to the negative control group (p <0,05)

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Gnetum gnemon, L., antihiperlipidemia, kolesterol total, HDL, trigliserida.
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 11508 not found.
Date Deposited:	05 Apr 2021 01:57
Last Modified:	05 Apr 2021 01:57
URI:	http://repository.unsri.ac.id/id/eprint/44795

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