UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN MELINJO (GNETUM GNEMON L. (LINN.)) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI BAKTERI ESCHERICHIA COLI

NURRAHMAH, ANISSA NADIA and Herlina, Herlina and Solihah, Indah (2021) UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN MELINJO (GNETUM GNEMON L. (LINN.)) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI BAKTERI ESCHERICHIA COLI. Undergraduate thesis, Sriwijaya University.

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Abstract

Melinjo (Gnetum gnemon L.) is widely used by people because health benefits, such as preventing cancer, antidiabetes, antioxidant, high nutritional food, inhibiting aging, and antibacterial. Melinjo contains active compounds such as alkaloids, flavonoids, steroids and tannins that have an antibacterial activity. Diarrhea caused by bacterial infection is still common in Indonesia. One type of bacteria that causes diarrhea is Escherichia coli. This research conducted by in vivo method using male white rats of Wistar strain induced by Escherichia coli. The treatment group was divided into 6 groups: normal, negative control, positive control, and groups with doses 150, 300, and 600 mg/kgBW. Negative control was given Na-CMC and positive control Gentamicin. The initial time diarrhea occurred 24-30 hours after administration of Escherichia coli suspension. The parameters feces weight, feces consistency, frequency diarrhea, body weight, number of Escherichia coli colonies feces dose 600 mg/kgBW had effect that was almost close to positive control. The results showed that anti-diarrheal effect dose 150 mg/kgBW 35.75%, dose 300 mg/kgBW 43.02%, dose 600 mg/kgBW 50.14%. This shows that ethanol extract melinjo leaves dose 600 mg/kgBW wasn’t significantly different from positive control. Effective Dose (ED50) Ethanol Extract Melinjo Leave as antidiarrheal was 578,2468 mg/kgBW. Keywords: Melinjo leaves, etanol extract, antibacterial, Escherichia coli

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Melinjo leaves, etanol extract, antibacterial, Escherichia coli
Subjects:	Q Science > QR Microbiology > QR1-502 Microbiology Q Science > QR Microbiology > QR171 Microorganisms in the animal body Q Science > QR Microbiology > QR75-99.5 Bacteria R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM265-267 Antibiotic therapy. Antibiotics R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Anissa Nadia Nurrahmah
Date Deposited:	09 Jun 2021 02:43
Last Modified:	09 Jun 2021 02:43
URI:	http://repository.unsri.ac.id/id/eprint/47487

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