Fitrya, Fitrya (2021) Toxicological Assessment of Parkia Speciosa Pod Ethanol Extract: The Acute and Sub-Chronic Oral Toxicity Test on Experimental Animal. International Journal of Pharmaceutical Research, 13 (3). pp. 130-136. ISSN 0975-2366
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Abstract
Parkia speciosa has been used traditionally for the treatment of diabetes, headache, and kidney failure in several countries such as Malaysia and Indonesia. This study tested the toxicity of its pod ethanol extract through acute and sub-chronic toxicity tests on experimental animal. Wistar rats were given orally a single dose of Parkia speciosa ethanol extract up to 5000 mg/kg for the acute toxicity test. Toxic symptoms and mortality were observed daily for 7 days. On the other hand, the rats were given the extract doses of 100, 200, 400, and 800 mg/kg/day for 28 days orally for sub-chronic toxicity test. A control group was given 10% Na CMC suspension. On the 29th day, blood of the rats was drawn and the rats were then sacrificed. The toxicity effects were observed through the several parameters namely, body weight, hematology, serum biochemistry, relative organ weight, and histopathology. The acute toxicity analysis showed no mortality and toxic symptoms until the dose of 5000 mg/kg so that the extract was categorized as low toxicity with LD50 value of > 5000 mg. In addition, the sub-chronic toxicity analysis showed insignificant alteration in body weight, serum biochemistry, and hematology (p > 0.05). However, white blood cells count and neutrophils levels of the female group were significantly different between test group and control group (p < 0.05). Furthermore, mild necrosis occurred at the 800 mg/kg group from histopathology analysis. In conclusion, the Parkia speciosa pod ethanol extract is relatively safe for oral administered with caution at high doses usage.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Parkia speciosa, toxicity test, acute, sub-chronic. |
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) |
| Divisions: | 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1) |
| Depositing User: | M.Si, Apt. Fitrya Fitrya |
| Date Deposited: | 17 Jun 2021 02:40 |
| Last Modified: | 17 Jun 2021 02:40 |
| URI: | http://repository.unsri.ac.id/id/eprint/48070 |
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