STABILITAS SELF-NANOEMULSIFYING SISTEM PEMBAWA EKSTRAK TEH PUTIH (CAMELLIA SINENSIS L.) PADA BEBERAPA MINYAK DAN SURFAKTAN YANG BERBEDA

UTAMI, WIDEA FITRI and Shiyan, Shaum (2022) STABILITAS SELF-NANOEMULSIFYING SISTEM PEMBAWA EKSTRAK TEH PUTIH (CAMELLIA SINENSIS L.) PADA BEBERAPA MINYAK DAN SURFAKTAN YANG BERBEDA. Undergraduate thesis, Sriwijaya University.

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Abstract

The content in white tea is proven to have many pharmacological activities, but there are some problems in terms of solubility and absorption so that its use in the oral route is still less effective. White tea extract was formulated in the form of SNE to overcome these problems and increase oral bioavailability so that it has high stability and reduces the dose and frequency of drug administration. This research was conducted to determine the stability of the SNE formula of several types of oils and surfactants based on qualitative analysis of the FTIR-ATR spectra pattern and combination of chemometric analysis. The formula was obtained from the Multilevel Categoric (MC) approach to the Design Expert (DX) by testing the stability of centrifugation, real time and freeze-thaw plus SNE characterization of white tea extract. The results of the characterization and centrifugation test of formulas 2 and 6 did not experience separation and precipitation. Freeze-thaw test only formula 4 which undergoes separation and precipitation and real time test all formulas are physically stable after treatment. Based on the FTIR-ATR spectral pattern, all formulas, both the real time and freeze-thaw methods, did not show any shift in functional groups. Absorbance data from the FTIR-ATR spectra entered in the chemometric analysis formed groups according to their characteristics. The 12 SNE formulas of white tea extract based on exploratory stability tests each have the ability to remain stable or not after going through several stability tests and are grouped based on their characteristics which are divided into 4 groups in real time and freeze-thaw methods. Keywords: FTIR-ATR, Chemometrics, Stability, White Tea, SNE Kandungan dalam teh putih terbukti memiliki banyak aktivitas farmakologis namun ada beberapa pemasalahan pada sisi kelarutan dan absorbsinya sehingga penggunaaannya pada rute oral masih kurang efektif. Ekstrak teh putih diformulasikan dalam bentuk SNE untuk mengatasi permasalahan tersebut dan meningkatkan bioavailabilitas oral sehingga memiliki stabilitas tinggi dan menurunkan dosis serta frekuensi pemberian obat. Penelitian ini dilakukan untuk mengetahui stabilitas formula SNE dari beberapa jenis minyak dan surfaktan berdasarkan analisis kualitatif pada pola spektra FTIR-ATR dan kombinasi analisis kemometrik. Formula didapatkan dari pendekatan Multilevel Categoric (MC) pada Design Expert (DX) dengan pengujian stabilitas sentrifugasi, real time dan freeze-thaw ditambah dengan karakterisasi SNE ekstrak teh putih. Hasil uji karakterisasi dan sentrifugasi formula 2 dan 6 tidak mengalami pemisahan dan pengendapan. Uji freeze-thaw hanya formula 4 yang mengalami pemisahan dan pengendapan dan uji real time semua formula stabil secara fisik setelah adanya perlakuan. Berdasarkan pola spektra FTIR-ATR semua formula baik pola pada metode real time maupun freeze-thaw tidak menunjukkan adanya pergeseran gugus fungsi. Data absorbansi dari spektra FTIR-ATR yang masuk dalam analisis kemometrik membentuk kelompok-kelompok sesuai dengan karakteristiknya. 12 formula SNE ekstrak teh putih berdasarkan eksplorasi uji stabilitas memiliki kemampuan masing-masing untuk tetap stabil atau tidak setelah melalui beberapa uji stabilitas dan mengelompok berdasarkan karakteristiknya yang terbagi dalam 4 kelompok pada metode real time dan freeze-thaw. Kata kunci: FTIR-ATR, Kemometrik, Stabilitas, Teh Putih, SNE

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	teknologi farmasi, bahan alam
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Widea Fitri Utami
Date Deposited:	07 Jun 2022 02:26
Last Modified:	07 Jun 2022 02:26
URI:	http://repository.unsri.ac.id/id/eprint/71847

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