FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLE PEMBAWA GLIBENKLAMID DENGAN MENGGUNAKAN ASAM STEARAT DAN VARIASI JUMLAH KOSURFAKTAN PEG 400

TERESYA, NAOMI and Syarif, Nirwan and Mardiyanto, Mardiyanto (2022) FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLE PEMBAWA GLIBENKLAMID DENGAN MENGGUNAKAN ASAM STEARAT DAN VARIASI JUMLAH KOSURFAKTAN PEG 400. Undergraduate thesis, Sriwijaya University.

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Abstract

The formulation and characterization of glibenclamide into nanoparticles is a new delivery system for the use of glibenclamide drugs. The manufacture of SLN is carried out using high speed homogenization and ultrasonication methods. The solid lipid nanoparticles glibenclamide formula consisted of stearic acid as a lipid matrix, tween 80 as a surfactant, polietilena glikol 400 as a cosurfactant, polivinil alkohol as a stabilizer and variations in the amount of polietilena glikol 400 in the three formulas, respectively 5 g, 10 g and 15 g. Solubility of solid lipid nanoparticles was tested using simulated method, that is SGF, SIF and HCl. Determination of the percent encapsulation efficiency (% EE) obtained results for the three formulas, including 88,4587±0.0085 (formula 1), 93,8709±0.0148 (formula 2), and 86,8466±0.0226 (formula 3). Formula 2 was characterized for physical properties using a particle size analyzer (PSA) so that the results for formula 2 were obtained, namely average particle size 167,0±0,6342 nm, range between 166.7 nm to 167 nm, polydispersity index 0.442±0.0145, and zeta potential -34,6±1,7146 mV. The heating-cooling stability test was carried out with a cycle test for 12 days, the results obtained in formula 2 which was slightly cloudy in white, there was no phase separation, and there was a precipitate. In the mechanical stability test, phase separation occurred in each formula. The results of the solubility test showed that solid lipid nanoparticle glibenclamide was soluble in aquadest, in SGF, in SIF and in HCl 5%. The conclusion from the research that has been done shows that the SLN glibenclamide preparation can be used as a new drug delivery system.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Glibenklamid, Solid Lipid Nanoparticles, Persen Efisiensi Enkapsulasi, Stabilitas
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Naomi Teresya
Date Deposited:	05 Aug 2022 08:19
Last Modified:	05 Aug 2022 08:19
URI:	http://repository.unsri.ac.id/id/eprint/76339

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