IDENTIFIKASI POLIMORFISME GIu298Asp (G894T) EKSON 7 GEN eNOS PADA PENDERITA NEFROPATI DIABETIK POPULASI MELAYU DI SUMATERA SELATAN

WIJAYA, SURYA and Saleh, Mgs. Irsan and Nasution, Nursiah (2012) IDENTIFIKASI POLIMORFISME GIu298Asp (G894T) EKSON 7 GEN eNOS PADA PENDERITA NEFROPATI DIABETIK POPULASI MELAYU DI SUMATERA SELATAN. Undergraduate thesis, Sriwijaya University.

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Abstract

Diabetic nephropathy is one of microvascular complications in type 2 diabetes mellitus which can cause chronic kidney failure. This complication has a significant correlation with Glu298Asp (G894T) polymorphism of exon 7 eNOS gene in several of global population because this type of polymorphism reduces eNOS gene activity and NOS3 production until l/2x fewer than normal, the protective factor of chronic kidney failure. Nevertheless, until now there is not a research about this fact in Melayu population, especially in South Sumatera. Because of that, the aim of this research is identifying Glu298Asp (G894T) polymorphism of exon 7 eNOS gene which is cut by enzyme Dpnll in patients with nephropathy diabetic of Melayu population in South Sumatera. This research was done in a descriptive study with cross sectional sample of 30 patients with diabetic nephropathy. Identification of Glu298Asp (G894T) polymorphism was done by using PCR and RFLP (restriction fragment length polymorphism) using enzyme Dpnll. This research found Glu298Asp (G894T) polymorphism of exon 7 eNOS gene with 0% homozygote mutant allele genotype (Asp-Asp/TT), 30%, heterozygote mutant allele (Glu-Asp/GT), and 70% wild type allele genotype'(Glu-Glu/GG) where the amount of T and G allele is 15% and 85% in patients with diabetic nephropathy of Melayu population in South Sumatera The conclusion of this research is the overview of allele G and wild-type genotype was more common in patients with diabetic nephropathy of Melayu population in South Sumatera.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	diabetic nephropathy, polymorphism, eNOS, Glu294Asp, G894T
Subjects:	R Medicine > RC Internal medicine > RC627.5-632 Metabolic diseases
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Mrs Furika Furika
Date Deposited:	24 Nov 2022 05:04
Last Modified:	24 Nov 2022 05:04
URI:	http://repository.unsri.ac.id/id/eprint/82238

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