PENGARUH FRAKSI NONPOLAR KAYU MANIS (CINNAMOMUM BURMANNII) TERHADAP KADAR KORTISOL TIKUS PUTIH MODEL INSOMNIA

PRATAMA, BARIAN MUCHTAR and Purnamasari, Septi and Hidayat, Rachmat (2022) PENGARUH FRAKSI NONPOLAR KAYU MANIS (CINNAMOMUM BURMANNII) TERHADAP KADAR KORTISOL TIKUS PUTIH MODEL INSOMNIA. Undergraduate thesis, Sriwijaya University.

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Abstract

Insomnia is a sleep disorder that reduces the quality of life. Insomnia affects the HPA Axis by increasing cortisol levels. Cinnamomum burmannii is a plant that has antiinflammatory and antioxidant activity. This study aims to determine effect of nonpolar fraction of cinnamon on cortisol levels. This study was an in vivo experimental study using a post-test only design and a control group at the Eureka Research Laboratory. Thirty male Wistar Rats were divided into six groups: normal control (Na-CMC 0,5%), negative control (PCPA), positive control (0.1 mg/KgBW estazolam), and Cinnamon Nonpolar Fraction group (CNF) 5 mg/KgBW, 10 mg/KgBW, and 20 mg/KgBW. CNF is obtained through the separating funnel method with n-hexane solvent from cinnamon simplicia macerated with 96% ethanol. Insomnia was induced in each group, except for the normal group, by intraperitoneal administration of 300 mg/KgBB p-chlorophenylalanine (PCPA) for two days. Administration of CNF and 0,5% Na-CMC was carried out with an intragastric tube for 14 days. The rats were euthanized and blood was taken from the abdominal aorta to measure cortisol levels in serum by the ELISA method. The data were analyzed using SPSS software with a statistical significance of p < 0.05. The mean cortisol levels for each group in ng/mL respectively were 30.340 ± 0.11402; 46.720 ± 0.13038; 38.340 ± 0.11402; 41.620 ± 0.13038; 33.560 ± 0.20736.; 32.640 ± 0.11402. The reduction in mean cortisol levels in the group receiving CNF was statistically significant (p <0.05) with a dose of 10 mg/KgBW and 20 mg/KgBW of CNF providing better efficacy than a dose of 0.1 mg/KgBB of estazolam. CNF has efficacy in reducing cortisol serum levels in the insomnia model of white rats Keywords: Cinnamomum burmannii, Nonpolar fraction, Insomnia, kortisol

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Cinnamomum burmannii, Fraksi nonpolar, Insomnia, kortisol
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Barian Muchtar Pratama
Date Deposited:	21 Dec 2022 12:28
Last Modified:	21 Dec 2022 12:28
URI:	http://repository.unsri.ac.id/id/eprint/84413

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