RASIONALITAS PENGGUNAAN ANTIDIABETIKA ORAL PADA PASIEN RAWAT INAP DIABETES MELITUS TIPE 2 DI RSUD PALEMBANG BARI PERIODE 1 SEPTEMBER 2010-31 AGUSTUS 2011

WINAS, ANCI and Kamaluddin, M. T. and Theodorus, Theodorus (2012) RASIONALITAS PENGGUNAAN ANTIDIABETIKA ORAL PADA PASIEN RAWAT INAP DIABETES MELITUS TIPE 2 DI RSUD PALEMBANG BARI PERIODE 1 SEPTEMBER 2010-31 AGUSTUS 2011. Undergraduate thesis, Sriwijaya University.

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Abstract

Background: Diabetes mellitus (DM) is one of degenerative disease_sthat will increase in the future. The prevalence of diabetes in the world has mcreased significantly. ft is estimated that by 2030 the prevalence of DM in Indonesia will reach 21.3 million people. This study aims to determine the rationality using of oral antidiabetics in diabetes mellitus type 2 patients hospitalized in Palembang Bari Hospital period 1 September 2010- 31 August 2011. Methods: Study of drug utilization was conducted at Palembang Bari Hospital began in October to December 2011. Population in this study was medical records of patients with Type 2 DMfrom 1 September 2010-31 August 2011. Samples were 36 medical records that appropriate with inclusion criteria. The data were analyzed by manual calculation. Results: The number of women patient with DM (20 medical records 55.56%) were higher than male (I 6 medical records 44.44%). The highest number of oral antidiabetic administration belongs to the age group of 51-60 years (33.33%). Generic drug was administered in 46 drugs (79.31%) compared to patent drug in 12 drugs (20.69%). Sulfonylurea was generic drug that was commonly prescribed in 25 drugs (43.10%). Combination of oral antidiabetic drugs (19 drugs 52.78%) more widely used compared to single administration. Groups of antidiabetic that prescribed most frequently were oral Sulfonylureas in 33 drugs (56.90%), Biguanid in 22 drugs (37.93%) and Alpha-glucosidase inhibitor in 3 drugs (5.17%). Metformin (Biguanid) was type of oral antidiabetic that used frequently by 22 drugs (37.93%) with 500 mg dosage and the frequency was three times a day in 12 drugs (54.55%), Glimepiride (Sulfonylurea) in 18 drugs (31.03%) which I mg dosage was given frequently in 11 drugs (61.11%) and frequency was once a day in 17 drugs (94.44%), Akarbose (Alpha-glucosidase inhibitors) in 3 drugs (5.17%) and overall using 50 mg dosage which frequency was three times a day. There were 502 interactions which had potential action as many as 41.04%, addictive 48.01%, antagonistic (7.37%), and 3.58% unknown. From 58 oral antidiabetics given, 50 drugs were followed-up (86.21%). Conclusion: Irrationality was found in the frequency of administration in 3 drugs (5.17%) and duration of administration in 12 medications (20.69%). Jn addition there was potentia i n nteraction between oral antidiabetics with other drugs by 41,04% and antagomstlc mteraction 7,37%.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Oral antidiabetic and rationality of drugs.
Subjects:	R Medicine > RC Internal medicine > RC627.5-632 Metabolic diseases
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Mrs Furika Furika
Date Deposited:	09 Jan 2023 03:12
Last Modified:	09 Jan 2023 03:12
URI:	http://repository.unsri.ac.id/id/eprint/85532

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