KESESUAIAN DIAGNOSIS HISTOPATOLOGI KARSINOMA DUKTAL DAN LOBULAR PAYUDARA DENGAN EKSPRESI E-CADHERIN DI RSUP Dr. MOHAMMAD HOESIN PALEMBANG

OKTARINA Z.D, MONA and Maulani, Heni and Rasjid HS., M. and Zulkharnain, M. (2011) KESESUAIAN DIAGNOSIS HISTOPATOLOGI KARSINOMA DUKTAL DAN LOBULAR PAYUDARA DENGAN EKSPRESI E-CADHERIN DI RSUP Dr. MOHAMMAD HOESIN PALEMBANG. Other thesis, Sriwijaya University.

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Abstract

Background. The mosi common breast carcinomas are ductal (40-70%) and lobular (5-15%) types. They have distinct histopathologycal features, but the challenge for the pathologists are sometimes boih features can appears on the same tumor in confusing pattern. Jn order to help distinguishing this two types carcinomas, there are many researchs for E-cadherin expression and proven as usefitl tools. This study want t o see the conformity between the histopathologycal diagnoscs with the E-cadherin expression. Methods. Seventy two samples of H&E-stained slides and paraffin blocks consists of 18 ductal carcinomas, 18 lobular carcinomas and 36 invasive carcinomas showing confusing histopathologycal features of both types (Januari 2008 - Juli 2011) from the pathologycal archieves of the Anatomical Pathology Laboratory of Dr. Mohammad Hoesin General Hospital, Palembang being reviewed, E-cadherin immunohistochemical stains were performed, evaluated independently by 2 pathologists; Kappa statistical test were performed. Result. Kappa value between the 2 pathologists are 0,380. From 27 cases of ductal carcinomas, the E-cadherin expression were positive in 25 cases, negative in 1 case, and both expression was seen in 1 case. Lobular carcinoma was found only 2 cases; both showed negative E-cadherin expression, meanwhile in the confusing cases: positive E-cadherin expression were observed in 21 cases, negative in 14 case, and 1 case was found with both positive and negative E-cadherin expression (Kappa value = 0,809). Conclusion. E-cadherin expression is strongly conform with the histopathologycal diagnoses (ductal carcinomas are positive; lobular carcinomas are negative), can be used as a useful diagnostic tool to differentiate ductal and lobular carcinomas of the breast; especially for the cases with confusing histopathologycal features.

Item Type:	Thesis (Other)
Uncontrolled Keywords:	ductal carcinomasy lobular carcinomas, E-cadherin expression
Subjects:	R Medicine > RG Gynecology and obstetrics > RG491-499 Diseases of the breast
Divisions:	04-Faculty of Medicine > 11718-Pathology Anatomy (Sp
Depositing User:	Mrs Furika Furika
Date Deposited:	01 Feb 2023 02:13
Last Modified:	01 Feb 2023 02:13
URI:	http://repository.unsri.ac.id/id/eprint/88839

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