UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI ETIL ASETAT DAUN UBI JALAR UNGU (Ipomoea batatas (L.)Lam) TERHADAP TIKUS PUTIH JANTAN DIINDUKSI SUPLEMEN TINGGI LEMAK

PRAPITASARI, RIZKI and Solihah, Indah and Agustiarini, Vitri (2022) UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI ETIL ASETAT DAUN UBI JALAR UNGU (Ipomoea batatas (L.)Lam) TERHADAP TIKUS PUTIH JANTAN DIINDUKSI SUPLEMEN TINGGI LEMAK. Undergraduate thesis, Sriwijaya University.

	Text RAMA_48201_08061181823019.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_48201_08061181823019_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (10MB) | Request a copy
Preview	Text RAMA_48201_08061181823019_0008038802_0016089302_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB) | Preview
	Text RAMA_48201_08061181823019_0008038802_0016089302_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (352kB) | Request a copy
	Text RAMA_48201_08061181823019_0008038802_0016089302_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (471kB) | Request a copy
	Text RAMA_48201_08061181823019_0008038802_0016089302_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (683kB) | Request a copy
	Text RAMA_48201_08061181823019_0008038802_0016089302_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (187kB) | Request a copy
	Text RAMA_48201_08061181823019_0008038802_0016089302_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (700kB) | Request a copy
	Text RAMA_48201_08061181823019_0008038802_0016089302_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy

Abstract

The ethyl acetate fraction of purple sweet potato leaves contains secondary metabolites of flavonoids, tannins, and phenols, which are thought to have antihyperlipidemic activity. The aim of this study was to determine the antihyperlipidemic activity of the ethyl acetate fraction of purple sweet potato leaves in male albino rats by measuring total cholesterol, triglycerides, HDL and LDL, as well as liver histopathology. In this study, rats were divided into 6 test groups, namely: normal control (standard diet), negative control (0.01% PTU, 0.5% NaCMC and high fat supplement), positive control (fenofibrate 19.76 mg /kg of body weight) and 3 groups. treatment group (dose 50 mg/kg, 100 mg/kg and 200 mg/kg). According to the results of the study, the percentage reduction in total cholesterol obtained in the treatment group at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg was 30.7%, 49.2%, 54.3%. The reduction in triglyceride levels obtained in the 50 mg/kg BW group was 30.8%, the 100 mg/kg BW dose was 50.8%, and the 200 mg/kg BW dose was 55.8%. The increase in HDL levels in the 50 mg/kg body weight group was 12.0%, in the 100 mg/kg body weight group - 20.0%, in the 200 mg/kg body weight group - 39.0%. The average decrease in LDL levels in the 50 mg/kg body weight group was 12.5%, in the 100 mg/kg body weight group - 9.3%, in the 200 mg/kg body weight group - 33.1%. Based on the results of studies for all treatment groups, the best dose was 200 mg/kg BB. Based on the relationship between the percentage reduction in hyperlipidemia parameters, the effective dose (ED50) of the ethyl acetate fraction of purple sweet potato leaves was 221.7 mg/kg body weight. The results of a macroscopic study of the liver in rats at doses of 50 mg/kg BW, 100 mg/kg BW, 200 mg/kg BW showed ballooning. The histopathological picture of the liver of rats showed that the dose fraction of 200 mg/kg of BB did not differ from the positive control group, in which necrosis and fattening were insignificant. This shows that the ethyl acetate fraction of purple sweet potato leaves has antihyperlipidemic activity.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Antihiperlipidemia, Fenofibrat,Ipomoea batatas (L.)Lam, PTU.
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Rizki Prapitasari
Date Deposited:	03 Feb 2023 04:37
Last Modified:	03 Feb 2023 04:37
URI:	http://repository.unsri.ac.id/id/eprint/89098

Actions (login required)

View Item