STUDI AKTIVITAS DIURETIK EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus)

SANTOSO, IWAN and Herlina, Herlina and Solihah, Indah (2019) STUDI AKTIVITAS DIURETIK EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus). Undergraduate thesis, Sriwijaya University.

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Abstract

Diuretic activity test of ethanol extract of melinjo leaves (Gnetum gnemon L.) on male white wistar strain (Rattus norvegicus) was carried out to study diuretic activity of melinjo leaves extract. Phytochemical screening containing ethanol extract of melinjo leaves contained compositions of flavonoids, tannins, saponins, and steroids. The ethanol extract of melinjo leaves used has a water soluble extract content and soluble ethanol extract content of 51.33% ± 0.1 and 48.66 ± 0.5%, moisture content and drying losses of 8.12 ± 0.028% and 8, 84 ± 0.028%, and total ash content and acid insoluble ash content of 8.66% ± 1.25 and 1.05% ± 0.1. Diuretic activity test was performed on wistar strain rats which were divided into 5 test groups, positive control group (20 mg/kgBW), normal control (1% Na CMC 2 ml/200gBW), and three study groups extract (125 mg/kgBW, 250 mg/kgBW and 500 mg/kgBW). From the observations, total urine volume was 5.5 mL in the positive control group and 2.172 mL in the normal control group. The group that received extracts (125 mg/kgBW, 250 mg/kgBW and 500 mg/kgBW) received total urine volume of 2.33 mL, 2.64 mL and 2.94 mL respectively. The potential diuretic value is 4.74%, 14.06% and 23.07%, respectively. The total urine obtained from each group was carried out by qualitative analysis of Na+, K+ and Cl- ion. The urine samples collected positively contain these three ions as K+ ions in the normal control group. ED50 value of melinjo leaf ethanol extract is 1.058 mg/kgBW. The conclusion of this study is that the ethanol extract of melinjo leaves has activity as a diuretic but is very low.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Gnetum gnemon L, diuretik activity, phytochemical screening, ED50, flavonoids
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Iwan Santoso
Date Deposited: 30 Jul 2019 04:32
Last Modified: 30 Jul 2019 04:32
URI: http://repository.unsri.ac.id/id/eprint/1179

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