POTENSI EKSTRAK ETANOL DAUN MINDI (Melia azedarach L)SEBAGAI DIURETIK TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR

ARDIAN, REZA and Herlina, Herlina and Indah, Sholihah (2019) POTENSI EKSTRAK ETANOL DAUN MINDI (Melia azedarach L)SEBAGAI DIURETIK TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

Potential research has been carried out diuretic extract of mindi leaf ethanol ( Melia azedarach L) against male white rats Wistar strain . Mindi leaf contains flavonoids which are potential as one of the diuretic agents. The total flavonoid content contained in the mindi leaf was 46.86 mg / g extract. This study used male white wistar rats which were divided into 5 groups, consisting of the normal control group (1% Na CMC 2 mL / 200 gBB), positive control group (20 mg / kgBB furosemide), and 3 groups of extract treatment doses ethanol leaf mindi namely 250 , 500 , and 1000 mg / kgBB. The test animals not given initial treatment were only acclimatized for one week. The urine volume of the test animal was measured after treatment every one hour for 6 hours. Diuretic activity tests are carried out in a cage of metabolites that can accommodate mouse urine. The urine volume of mice is measured and analyzed qualitatively on K + , Na + , and Cl - ions . Furosemide as a positive control produces the most urine volume, which is equal to 5.48 ml. The ethanol extract of mindi leaves at a dose of 1000 mg / kgBB resulted in a total urine volume of 4.10 mL and had the highest diuretic activity compared to other extract doses of 58.18 %. ED 50 value of 828.775 mg / kgBB. At furosemide and Mindi leaf ethanol extract showed positive results in mouse urine contained ions K +, Na + and Cl -. Based on this study it was concluded that leaves of mindi ethanol extract has the potential for diuretics with the same mechanism of action as furosemide.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: Melia azedarach L, aktivitas diuretik, flavonoid total
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: 08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User: Reza Ardian
Date Deposited: 30 Jul 2019 04:20
Last Modified: 30 Jul 2019 04:20
URI: http://repository.unsri.ac.id/id/eprint/1195

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