ISOLASI STEROID DARI FRAKSI AKTIF SITOTOKSIK KAYU AKAR SARI RAPET (Ficus Deltoidea Jack)

ERLINA, NELLY and Elfita, Elfita and Ferlinahayati, Ferlinahayati (2002) ISOLASI STEROID DARI FRAKSI AKTIF SITOTOKSIK KAYU AKAR SARI RAPET (Ficus Deltoidea Jack). Undergraduate thesis, Sriwijaya University.

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Abstract

Steroid had been isolated from cytotoxic active fraction of the root wood Sari Rapet’s by maseration method with methanol as the solven. Continuing with fractionation vvith increasing by polarity : n-hexane, dichloromethane and ethylacetate. n-Hexane fraction showed the highest cytotoxic activity with LC50 =151,71 ppm. Separation and purification to n-hexasane fraction gave needle’s crystal (Mp : 133-134°C) that positif test to the steroid. The needle’s crystal gave 1 spot on TLC with varying eluen and showed 1 peak (Rt 5,02 minutes) in GC chromatogram. The Infrared spectra gave absorption peak at 3428,5 cm'1, 2934,8 and 2848,7 cm*1, 1660,5 cm"1,1464,4 cm'1, 1381,3 cm'1, 1053,3 cm'1 and 837,8 cm'1,that indicated fungsional group of O-H, C-H olefinic. C=C isolated, C-H cyclopenthane, C-H isopropyl, C-0 alkohol and C-H olefinic with 3 substituen respectively. The Massa Spectra exihibited a molecular formula C29H50O. Base on spectroscopy data and compare data base librarv of massa spectra the steroid suggested as sterol group that is stigmast-7-en-3-ol (5 betha, 3 alpha, 24S).

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Steroid, Fraksi Aktif Sitotoksik Kayu Akar Sari Rapet (Ficus Deltoidea Jack)
Subjects:	Q Science > QD Chemistry > QD241-441 Organic chemistry
Divisions:	08-Faculty of Mathematics and Natural Science > 47201-Chemistry (S1)
Depositing User:	Mrs Furika Furika
Date Deposited:	30 Mar 2022 05:46
Last Modified:	30 Mar 2022 05:46
URI:	http://repository.unsri.ac.id/id/eprint/67033

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