UJI ANTIHIPERURISEMIA EKSTRAK ETIL ASETAT BATANG KAYU KUNING (ARCANGELISIA FLAVA) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR

KAMILIYA, NADHIRA and Fatmawati, Fatmawati and Oktharina, Eka Handayani (2023) UJI ANTIHIPERURISEMIA EKSTRAK ETIL ASETAT BATANG KAYU KUNING (ARCANGELISIA FLAVA) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

	Text RAMA_11201_04011282025088.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (20MB) | Request a copy
	Text RAMA_11201_04011282025088_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (7MB) | Request a copy
	Text RAMA_11201_04011282025088_0009097004_0011108705_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (6MB)
	Text RAMA_11201_04011282025088_0009097004_0011108705_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_11201_04011282025088_0009097004_0011108705_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (1MB) | Request a copy
	Text RAMA_11201_04011282025088_0009097004_0011108705_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_11201_04011282025088_0009097004_0011108705_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (164kB) | Request a copy
	Text RAMA_11201_04011282025088_0009097004_0011108705_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (2MB) | Request a copy
	Text RAMA_11201_04011282025088_0009097004_0011108705_07_lamp.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy

Abstract

Background: Stem of yellow wood (Arcangelisia flava) is a plant that are efficacious as an antihyperuricemic. This is because it contains secondary metabolites in the form of alkaloids, flavonoids, terpenoids, and tannins. Previous research conducted in vitro research on ethyl acetate extract from stem of the yellow wood (Arcangelisia flava) which has been proven to be antihyperuricemic. This study tested the antihyperuricemic effect of ethyl acetate extract from stem of the yellow wood (Arcangelisia flava) on male white Wistar rats Methods: In vivo experimental research with a randomized prepost-test control group design using male white rats (n = 25) in hyperuricemia conditions divided into 5 groups: negative control (Na-CMC), positive control (Allopurinol), and 3 dose levels of ethyl acetate extract from stem of the yellow wood (Arcangelisia flava), namely 100 mg/kg BW, 200 mg /kg BW, and 400 mg /kg BW. Uric acid levels were measured on the 0th, 4th, and 7th. The uric acid concentration was calculated manually using a formula Results: Giving ethyl acetate extract from stem of the yellow wood (Arcangelisia flava) dose I (100 mg/kg BW), dose II (200 mg/kg BW), and dose III (400 mg/kg BW) for 7 days can reduce serum uric acid levels in rats. Based on statistical analysis, it was found that ethyl acetate extract from stem of the yellow wood (Arcangelisia flava)can reduce uric acid levels by more than 50%. Thus, administering the smallest dose namely dose I (100 mg/kg BW) has the potential to reduce serum uric acid levels. Conclusion: ethyl acetate extract from stem of yellow wood (Arcangelisia flava) can reduce serum uric acid levels in hyperuricemic conditioned wistar male white rats. Keywords: Arcangelisia flava, antihyperuricemic, xanthine oxidase inhibitors, serum uric acid

Item Type:	Thesis (Undergraduate)
Subjects:	R Medicine > R Medicine (General) > R856-857 Biomedical engineering. Electronics. Instrumentation > R857.M3.B56854 Biomedical materials. Stem cells--Therapeutic use. Regenerative medicine--Materials. TECHNOLOGY & ENGINEERING / Material Science. MEDICAL / Biotechnology
Divisions:	04-Faculty of Medicine > 11201-Medicine (S1)
Depositing User:	Nadhira Kamiliya
Date Deposited:	18 Dec 2023 04:50
Last Modified:	18 Dec 2023 04:50
URI:	http://repository.unsri.ac.id/id/eprint/134439

Actions (login required)

View Item