UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR SUB MIKROEMULSI EKSTRAK DAUN SAMBILOTO DENGAN KOMBINASI TWEEN 80 DAN PEG-400 TERHADAP TIKUS GALUR WISTAR

RUSYADI, DIAN ARIFANDO and Agustiarini, Vitri and Amriani, Annisa (2025) UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR SUB MIKROEMULSI EKSTRAK DAUN SAMBILOTO DENGAN KOMBINASI TWEEN 80 DAN PEG-400 TERHADAP TIKUS GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

	Image RAMA_48201_08061182126014_cover.jpg - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (376kB) | Request a copy
	Text RAMA_48201_08061182126014.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (3MB) | Request a copy
	Text RAMA_48201_08061182126014_TURNITIN.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (5MB) | Request a copy
	Text RAMA_48201_08061182126014_0016089302_0029128405_01_front_ref.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (795kB)
	Text RAMA_48201_08061182126014_0016089302_0029128405_02.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (394kB) | Request a copy
	Text RAMA_48201_08061182126014_0016089302_0029128405_03.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (179kB) | Request a copy
	Text RAMA_48201_08061182126014_0016089302_0029128405_04.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (621kB) | Request a copy
	Text RAMA_48201_08061182126014_0016089302_0029128405_05.pdf - Accepted Version Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (31kB) | Request a copy
	Text RAMA_48201_08061182126014_0016089302_0029128405_06_ref.pdf - Bibliography Restricted to Repository staff only Available under License Creative Commons Public Domain Dedication. Download (248kB) | Request a copy
	Text RAMA_48201_08061182126014_0016089302_0029128405_07_lamp.pdf - Accepted Version Available under License Creative Commons Public Domain Dedication. Download (1MB)

Abstract

Sambiloto has secondary metabolite compounds that are active as anti-inflammatory, antioxidant and antibacterial which have the potential to be developed into sub-microemulsion preparations for burns. This study aims to provide a sub-microemulsion preparation of sambiloto leaf extract (Andrographis paniculata) with a combination of Tween 80 and PEG-400 as an innovative preparation and burn activity test against the Wistar strain. This study was divided into 5 treatment groups, namely the normal control group, positive control (Tekasol), negatif control, 1% sambiloto cream and 1% sambiloto extract sub-microemulsion. Based on the evaluation results, the 1% sambiloto extract sub-microemulsion preparation had an average particle size of 97.396 ± 36.108 nm, and a polydispersity index of 0.247 ± 0.026 with an adsorption efficiency of 99.401 ± 0.002%. The results of the burn treatment test on Wistar rats obtained a positive control group of 90.60 ± 2.68%, negatif control 62.88 ± 2.30%, 1% sambiloto cream 86.47 ± 2.64% and 1% sambiloto microemulsion sub extract 92.31 ± 1.02%. Based on the results of the burn healing activity, the 1% sambiloto extract sub microemulsion group showed good wound healing results compared to the positive control. The results of the histopathology of the sub microemulsion group showed 88% tissue regeneration in the formation of new epidermis and 90% dermis tissue regeneration characterized by high fibroblasts, dominant collagen deposition and low inflammatory cells that were no different from the normal group.

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Andrographis paniculata, luka bakar, sub mikroemulsi.
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Dian Arifando Rusyadi
Date Deposited:	26 Feb 2025 03:31
Last Modified:	26 Feb 2025 03:31
URI:	http://repository.unsri.ac.id/id/eprint/167754

Actions (login required)

View Item