UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR SUBMIKRO EMULSI EKSTRAK DAUN SAMBILOTO DENGAN KOMBINASI TWEEN 20 DAN PEG-400 TERHADAP TIKUS GALUR WISTAR

SUSANTI, MELLYANI ANGELICA and Agustiarini, Vitri and Amriani, Annisa (2025) UJI AKTIVITAS PENYEMBUHAN LUKA BAKAR SUBMIKRO EMULSI EKSTRAK DAUN SAMBILOTO DENGAN KOMBINASI TWEEN 20 DAN PEG-400 TERHADAP TIKUS GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

Andrographis paniculata (Burm.f.) Nees) contains andrografolid, a compound that has anti-inflammatory, antibacterial, and antioxidant activities to accelerate burn wound healing. This study evaluated the preparation of submicro emulsion of bitter melon leaf extract with Tween 20 and PEG-400 at a concentration of 10% and tested the burn wound healing activity in Wistar rats. This study was divided into 5 treatment groups in the form of normal, positive (tekasol), negative, 1% sambiloto cream and 1% submicro emulsion. The characterization of submicro emulsion showed a transparent green, distinctive aroma and a liquid texture and pH value of 5.3±0.173; viscosity 2.807±0.270cP; density 1.065±0.002gr/cm3; andrographolide content 19.44±0.34%; entrapment efficiency 95.97±0.14%; globul size 175.733±13.081nm; polydispersity index 0.315±0.026; zeta potential 30.6±0.458mV and irritation scoring was 0. Burn wound activity test observed the time of scab formation and detachment, measuring burn area and %Recovery. The 1% sambiloto submicro emulsion showed time of scab formation and detachment on the 4th and 12th with %Recovery 92.05±0.93%, which is greater than 1% sambiloto cream (85.05±1.99%) and the negative group (62.88±3.67%). Histopathological analysis showed epithelial and collagen density as well as the distribution of inflammatory cells that did not dominate in the submicron emulsion 1%. ANOVA results confirmed significant differences in burn healing between the submicro emulsion and 1% sambiloto cream (p<0.05). Keywords: Burn wound, sambiloto, scab, submicro emulsion

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Keropeng, luka bakar, sambiloto, submikro emulsi
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Mellyani Angelica Susanti
Date Deposited:	28 Feb 2025 04:17
Last Modified:	28 Feb 2025 04:17
URI:	http://repository.unsri.ac.id/id/eprint/167810

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