PENGARUH PENGGUNAAN ANTIKOLINERGIK TERHADAP GANGGUAN FUNGSI KOGNITIF PASIEN SKIZOFRENIA PARANOID RAWAT JALAN DI RUMAH SAKIT ERNALDI BAHAR PROVINSI SUMATERA SELATAN

MAHARANI, CAHYA AULIA and Novita, Rennie Puspa and Agustiarini, Vitri (2025) PENGARUH PENGGUNAAN ANTIKOLINERGIK TERHADAP GANGGUAN FUNGSI KOGNITIF PASIEN SKIZOFRENIA PARANOID RAWAT JALAN DI RUMAH SAKIT ERNALDI BAHAR PROVINSI SUMATERA SELATAN. Undergraduate thesis, Sriwijaya University.

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Abstract

Paranoid schizophrenia is the most common type of schizophrenia, characterized by difficulty distinguishing between reality and thoughts, which impacts cognitive processes. Patients with this condition have particular vulnerability to medication side effects, especially anticholinergics that can affect cognitive function. This study aimed to analyze the effect of anticholinergic use on cognitive function impairment in outpatients with paranoid schizophrenia at Ernaldi Bahar Hospital, South Sumatra Province. An observational study with a cross-sectional design was conducted on 37 paranoid schizophrenia outpatients during November-December 2024. Data collection included medical record review and interviews, with cognitive function assessment using the Six-item Cognitive Impairment Tests (6 CIT). Statistical analysis was performed using the Chi-square test. The distribution of anticholinergic use showed level 0 at 22 drugs (22.22%), level 1 at 23 drugs (23.24%), level 2 at 9 drugs (9.09%), and level 3 at 45 drugs (45.45%). Cognitive function evaluation in patients using anticholinergics revealed 2 patients (5.40%) with normal cognitive function, 5 patients (13.51%) with mild cognitive impairment, and 30 patients (81.09%) with severe cognitive impairment. Statistical analysis demonstrated a significant effect of anticholinergic use on cognitive function impairment (p = 0.004). Keywords: Paranoid Schizophrenia, Anticholinergic, Cognitive Function Impairment

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Skizofrenia Paranoid, Antikolinergik, Gangguan Fungsi Kognitif
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Cahya Aulia Maharani
Date Deposited:	03 Mar 2025 04:20
Last Modified:	03 Mar 2025 04:20
URI:	http://repository.unsri.ac.id/id/eprint/167818

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