UJI AKTIVITAS DIURETIK EKSTRAK ETANOL HERBA SIRIH CINA (Peperomia pellucida. L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR

KIRANA, DIVA SAVIRA and Fitrya, Fitrya and Novita, Rennie Puspa (2025) UJI AKTIVITAS DIURETIK EKSTRAK ETANOL HERBA SIRIH CINA (Peperomia pellucida. L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR. Undergraduate thesis, Sriwijaya University.

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Abstract

Chinese Betel Herb Ethanol Extract (Peperomia pellucida. L.) is known to contain secondary metabolites, including phenolic compounds that are suspected to have the potential to be diuretics. This study aims to evaluate the diuretic effect of ethanol extract of Chinese betel herb. A total of 30 mice were divided into six treatment groups: normal group (given aquades), negative group (given NaCl 4.5%), positive group (given furosemide 20 mg/kgBW), and test groups I, II, and III which were given Chinese betel herb ethanol extract at doses of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW, respectively. The observed parameters included an increase in urine volume and levels of Na+, K+, and Cl- ions. The results showed that the administration of Chinese betel herb ethanol extract at a dose of 400 mg/kgBW significantly increased urine volume compared to the negative and positive control group (p<0.05) with the highest diuretic potential of 170.71%. Statistical analysis showed that there was a significant difference in the levels of Na⁺, K⁺, and Cl⁻ ions between the treatment groups (p<0.05). The effective dose (ED50) of Chinese betel herb ethanol extract was determined to be 104.08 mg/kgBW. Keywords: Diuretic, Ion levels, Peperomia pellucida. L, Phenolic

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Diuretik, Fenolik, Kadar Ion, Peperomia pellucida .L
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Diva Savira Kirana
Date Deposited:	03 Mar 2025 04:23
Last Modified:	03 Mar 2025 04:23
URI:	http://repository.unsri.ac.id/id/eprint/167858

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