PREPARASI DAN KARAKTERISASI SUBMIKRO PARTIKEL KITOSAN-ALGINAT PEMBAWA EKSTRAK ETANOL DAUN NANGKA (ARTOCARPUS HETEROPHYLLUS LAM.) DENGAN VARIASI WAKTU SONIKASI

DELMONDA, VABIOLA BESTI and Mardiyanto, Mardiyanto and Rennie, Puspa Novita (2020) PREPARASI DAN KARAKTERISASI SUBMIKRO PARTIKEL KITOSAN-ALGINAT PEMBAWA EKSTRAK ETANOL DAUN NANGKA (ARTOCARPUS HETEROPHYLLUS LAM.) DENGAN VARIASI WAKTU SONIKASI. Undergraduate thesis, Sriwijaya University.

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Abstract

Research on the preparation and characterization of submicro particles chitosan-alginate carrier of ethanol extract of jackfruit leaf with sonication time variation has been done. This research aims to determine the optimal sonication time and to determine the characterizations of submicro particles including particle size, PDI, %EE, zeta potensial and XRD spectrum. This research began with extraction process on jackfruit leaves using maceration method with 96% ethanol solvent continued with phytochemical scrinning. The ionic gelation was chosen in the making of submicro particles with a component consisting of jackfruit leaf extract, chitosan, natrium alginate, and CaCl2 as a crosslinker with sonication time variation 15, 30 and 60 minutes. The best formula obtained is at a time variation of 60 minutes with an encapsulation efficiency value of 95,863%. The particle size characteristics of the formula obtained were 244,2 nm; PDI 0,227; and zeta potensial +26,367. Based on the XRD spectrum of the best formula, it is known that submicro particles of jackfruit leaf extract has an amorphous form. The results of one way ANOVA, post hoc Tukey and LSD parametric analysis showed differences in sonication time affected time %EE of each formula with a significance value of p<0,05. Keyword(s): Jackfruit leaf, Artocarpus heterophyllus Lam., chitosan, natrium alginate, time sonication.

Item Type:	Thesis (Undergraduate)
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) R Medicine > RS Pharmacy and materia medica > RS192-199 Pharmaceutical technology
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	Users 7250 not found.
Date Deposited:	18 Aug 2020 03:36
Last Modified:	18 Aug 2020 03:36
URI:	http://repository.unsri.ac.id/id/eprint/32974

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