UJI AKTIVITAS HEPATOPROTEKTOR EKSTRAK ETANOL DAUN CEMPEDAK (ARTOCARPUS CHAMPEDEN) DAN HISTOPATOLOGI HEPAR TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI CCl4

ALVIONITA, ELVARA and Miksusanti, Miksusanti and Solihah, Indah (2021) UJI AKTIVITAS HEPATOPROTEKTOR EKSTRAK ETANOL DAUN CEMPEDAK (ARTOCARPUS CHAMPEDEN) DAN HISTOPATOLOGI HEPAR TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR TERINDUKSI CCl4. Undergraduate thesis, Sriwijaya University.

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Abstract

The leaves of cempedak (Artocarpus champeden) contain secondary metabolites in the form of flavonoid compounds which can be potential hepatoprotectors. This study aims to determine the effect of giving cempedak (Artocarpus champeden) leaf ethanol extract on the histopathological image of the liver of male white rats induced by carbon tetrachloride (CCl4) based on measurement parameters of SGPT and SGOT levels, macroscopic image and histopathology of rat liver organs. The leaves of cempedak (Artocarpus champeden) were extracted using 96% ethanol for 2x24 hours. Testing of hepatoprotector activity was carried out for 16 days using 30 rats which were divided into 6 treatment groups, namely the normal control group (Na CMC 1%), positive (silimarin 200 mg / kgBW), negative (CCl4 1 mL / kgBB), and the ethanol extract test group of cempedak leaves with a dose of 250, 500 and 1000 mg / kgBB. The results showed that the ethanol extract of cempedak leaves could be efficacious as a hepatoprotector with% hepatoprotector effect (% EH) for SGPT and SGOT levels in test group I of 54,16% and 47,92%, test group II of 76,70% and 65,80% and the third test group of 97.66% and 84,19%. The results showed that the ethanol extract of cempedak leaves significantly (p <0.05) reduced SGPT and SGOT levels compared to the negative group and had an effect on the histopathological picture of the liver of CCl4 induced rats. Based on the relationship between% hepatoprotector and extract dose, the effective dose value (ED50) of ethanol extract of Cempedak SGPT and SGOT leaves was 228,38 mg/kgBB and 273,99 mg/kgBB. Hepatoprotector activity was indicated by a decrease in SGPT and AST levels as well as a microscopic view of the liver. Key words : Artocarpus champeden (Lour.) Stokes, Hepatoprotector, Extraction, SGPT, SGOT, Histopathology, Liver Microscopic, Cempedak leaf ethanol extract

Item Type:	Thesis (Undergraduate)
Uncontrolled Keywords:	Artocarpus champeden (Lour.) Stokes, Hepatoprotektor, Ekstraksi, SGPT, SGOT, Histopatologi, Mikroskopik hati, Ekstrak etanol daun cempedak
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	08-Faculty of Mathematics and Natural Science > 48201-Pharmacy (S1)
Depositing User:	ELVARA ALVIONITA
Date Deposited:	04 Aug 2021 07:18
Last Modified:	04 Aug 2021 07:18
URI:	http://repository.unsri.ac.id/id/eprint/51263

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