Sudirman, Sabri (2019) The Ameliorative Effects of Eucheuma cottonii Extract on Inflammatory Functions: Bowel Disease and Osteoarthritis. Universitas Sriwijaya. (Unpublished)
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Abstract
Inflammatory bowel disease (IBD) is a known medical burden in most developed countries and a significant cause of morbidity. The IBD label includes Crohn's disease and ulcerative colitis. Osteoarthritis (OA) is a common form of arthritis diseases, characterized by degeneration of articular cartilage, and leading to joint dysfunction. Some strategies have been used to manage these diseases including pharmacological and non-pharmacological. The first strategy uses drugs and seems effective for a short-time but have some side effects such as increased risk of gastrointestinal and cardiovascular diseases as well as seem not effective for a long time. Seaweeds have received much attention in the pharmacological application due to its various therapeutic properties, including the anti-inflammation and antioxidant effects. Therefore, this study aimed to investigate the ameliorative effects of red seaweed Eucheuma cottonii extract (ECE) in a mice model of colitis and an OA model in obese rat. Colitis was induced in male BALB/c mice by the administration of 2.5% (w/v) dextran sulfate sodium (DSS) for 7 days. After treatment, ECE administration protected against weight loss and decreased the colon weight per length ratio. It also decreased proinflammatory cytokine expressions, increased interleukin (IL)-10 level, and reduced colonic damage. Therefore, a dietary polysaccharide from ECE suppressed DSS-induced bowel inflammation, thereby becoming a promising candidate for the treatment of colitis. For OA model, an anterior cruciate ligament transection with partial medial meniscectomy surgery (ACLT+MMx) to induce osteoarthritis characteristics in obese rats. The male Sprague-Dawley rats were fed a high-fat diet for 12 weeks before the surgery. Treatment with ECE for 5 weeks decreased the body weight, triglyceride, and total cholesterol (TC) levels, and the TC/high-density lipoprotein-cholesterol ratio in obese rats. ECE also downregulated the expression of proinflammatory cytokines, suppressed nuclear factor-kappa B and extracellular-signal-regulated kinase-1/2 expressions, resulting in decreased levels of matrix metalloproteinase (MMP)-1 and MMP-13 and attenuated cartilage degradation. These results demonstrated that the dietary polysaccharide from ECE suppressed OA development in obese rats, suggesting its potential efficacy against OA.
| Item Type: | Other |
|---|---|
| Subjects: | S Agriculture > SH Aquaculture. Fisheries. Angling > SH1-691 Aquaculture. Fisheries. Angling S Agriculture > SH Aquaculture. Fisheries. Angling > SH334.5-334.7 Fishery technology S Agriculture > SH Aquaculture. Fisheries. Angling > SH334.9-336.5 Fishery processing |
| Divisions: | 05-Faculty of Agriculture > 54244-Fisheries Product Technology (S1) |
| Depositing User: | Sabri Sudirman |
| Date Deposited: | 11 Apr 2023 10:10 |
| Last Modified: | 11 Apr 2023 10:10 |
| URI: | http://repository.unsri.ac.id/id/eprint/92936 |
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